Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1984 Aug;82(4):801–808. doi: 10.1111/j.1476-5381.1984.tb16476.x

Pharmacological investigations of the vasodilator nerves supplying the duck's foot.

C Bell, A C Rome
PMCID: PMC1986930  PMID: 6434012

Abstract

Vasodilator responses to electrical nerve stimulation and to various putative autonomic inhibitory neurotransmitters were studied in the Krebs-perfused foot of the domestic duck. Electrical stimulation resulted in frequency-dependent vasoconstrictor responses which were abolished by the infusion of guanethidine. After abolition of the vasoconstriction, electrical stimulation produced a frequency-dependent vasodilatation. The putative inhibitory transmitter substances tested were substance P, somatostatin, vasoactive intestinal polypeptide, adenosine triphosphate and dopamine. Of these only dopamine produced dilator responses similar in appearance to those following nerve stimulation. Infusion of metoclopramide (170 microM) greatly reduced dilator responses to nerve stimulation and to dopamine but not those to glyceryl trinitrate. These results suggest that the vasculature of the duck foot may be supplied by dopaminergic vasodilator nerves.

Full text

PDF
801

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baudinette R. V., Loveridge J. P., Wilson K. J., Mills C. D., Schmidt-Nielsen K. Heat loss from feet of herring gulls at rest and during flight. Am J Physiol. 1976 Apr;230(4):920–924. doi: 10.1152/ajplegacy.1976.230.4.920. [DOI] [PubMed] [Google Scholar]
  2. Bell C. Dopamine as a postganglionic autonomic neurotransmitter. Neuroscience. 1982 Jan;7(1):1–8. doi: 10.1016/0306-4522(82)90147-6. [DOI] [PubMed] [Google Scholar]
  3. Bell C. Dual vasoconstrictor and vasodilator innervation of the uterine arterial supply in the guinea pig. Circ Res. 1968 Aug;23(2):279–289. doi: 10.1161/01.res.23.2.279. [DOI] [PubMed] [Google Scholar]
  4. Bell C., Gillespie J. S., Macrae I. M. Release of noradrenaline and dopamine by nerve stimulation in the guinea-pig and rat vas deferens. Br J Pharmacol. 1984 Mar;81(3):563–569. doi: 10.1111/j.1476-5381.1984.tb10110.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bell C., Lang W. J. Evidence for dopaminergic vasodilator innervation of the canine paw pad. Br J Pharmacol. 1979 Nov;67(3):337–343. doi: 10.1111/j.1476-5381.1979.tb08685.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bell C., Stubbs A. Localization of vasodilator dopamine receptors in the canine hindlimb. Br J Pharmacol. 1978 Oct;64(2):253–257. doi: 10.1111/j.1476-5381.1978.tb17297.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bernstein M. H. Vascular responses and foot temperature in pigeons. Am J Physiol. 1974 Jun;226(6):1350–1355. doi: 10.1152/ajplegacy.1974.226.6.1350. [DOI] [PubMed] [Google Scholar]
  8. Bolton T. B., Bowman W. C. Adrenoreceptors in the cardiovascular system of the domestic fowl. Eur J Pharmacol. 1969 Jan;5(2):121–132. doi: 10.1016/0014-2999(69)90020-x. [DOI] [PubMed] [Google Scholar]
  9. Burnstock G. Purinergic nerves. Pharmacol Rev. 1972 Sep;24(3):509–581. [PubMed] [Google Scholar]
  10. Campbell G., Gibbins I. L., Morris J. L., Furness J. B., Costa M., Oliver J. R., Beardsley A. M., Murphy R. Somatostatin is contained in and released from cholinergic nerves in the heart of the toad Bufo marinus. Neuroscience. 1982;7(9):2013–2023. doi: 10.1016/0306-4522(82)90116-6. [DOI] [PubMed] [Google Scholar]
  11. Day M. D., Blower P. R. Cardiovascular dopamine receptor stimulation antagonized by metoclopramide. J Pharm Pharmacol. 1975 Apr;27(4):276–278. doi: 10.1111/j.2042-7158.1975.tb10699.x. [DOI] [PubMed] [Google Scholar]
  12. Franco R., Costa M., Furness J. B. Evidence for the release of endogenous substance P from intestinal nerves. Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):195–201. doi: 10.1007/BF00507103. [DOI] [PubMed] [Google Scholar]
  13. Gillespie J. S. The rat anococcygeus muscle and its response to nerve stimulation and to some drugs. Br J Pharmacol. 1972 Jul;45(3):404–416. doi: 10.1111/j.1476-5381.1972.tb08097.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hillman P. E., Scott N. R., van Tienhoven A. Vasomotion in chicken foot: dual innervation of arteriovenous anastomoses. Am J Physiol. 1982 May;242(5):R582–R590. doi: 10.1152/ajpregu.1982.242.5.R582. [DOI] [PubMed] [Google Scholar]
  15. Johansen K., Millard R. W. Cold-induced neurogenic vasodilatation in skin of the giant fulmar Macronectes giganteus. Am J Physiol. 1974 Dec;227(6):1232–1235. doi: 10.1152/ajplegacy.1974.227.6.1232. [DOI] [PubMed] [Google Scholar]
  16. Lembeck F., Holzer P. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):175–183. doi: 10.1007/BF00500282. [DOI] [PubMed] [Google Scholar]
  17. Lundberg J. M., Anggård A., Fahrenkrug J., Hökfelt T., Mutt V. Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1651–1655. doi: 10.1073/pnas.77.3.1651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MELLANDER S. Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat. Acta Physiol Scand Suppl. 1960;50(176):1–86. [PubMed] [Google Scholar]
  19. Marshall J. M. The influence of the sympathetic nervous system on individual vessels of the microcirculation of skeletal muscle of the rat. J Physiol. 1982 Nov;332:169–186. doi: 10.1113/jphysiol.1982.sp014408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. McGregor D. D. Noncholinergic vasodilator innervation in the feet of ducks. Am J Physiol. 1979 Aug;237(2):H112–H117. doi: 10.1152/ajpheart.1979.237.2.H112. [DOI] [PubMed] [Google Scholar]
  21. Pernow B., Rosell S. Effect of substance P on blood flow in canine adipose tissue and skeletal muscle. Acta Physiol Scand. 1975 Jan;93(1):139–141. doi: 10.1111/j.1748-1716.1975.tb05800.x. [DOI] [PubMed] [Google Scholar]
  22. Woodman O. L., Rechtman M. P., Lang W. J. A comparison of the responses to some dopamine-receptor agonists and antagonists in the isolated perfused rat kidney. Arch Int Pharmacodyn Ther. 1980 Dec;248(2):203–211. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES