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. 1984 Jun;82(2):329–338. doi: 10.1111/j.1476-5381.1984.tb10767.x

The effect of acetylsalicylic acid on renal function in the Pekin duck.

D A Gray, N Langrieger, J Reschmaier, E Simon
PMCID: PMC1987045  PMID: 6428501

Abstract

The acute effects of intravenously administered lysine-acetylsalicylic acid (ASA) on renal function in the Pekin duck have been studied with special reference to possible interactions with the antidiuretic hormone, arginine vasotocin (AVT), in the control of renal water and solute output. ASA produces an immediate increase in urine flow rate which is dose-related in the range 25 to 100 mg kg-1 and is associated with a slight reduction in urine osmolality, but an overall increase in renal osmolal excretion affecting Na+, Cl- and K+ to approximately equal extents. The effects, which are similar in both saltwater and freshwater adapted ducks infused with hyposmotic saline or glucose solution, can also be produced by similar doses of sodium salicylate (SA). The mechanism of action is probably not related to inhibition of prostaglandin synthetases. There is no change in the glomerular filtration rate or peripheral blood pressure following the ASA injection. There is no change in the circulating level of AVT; however, preliminary studies do not exclude the possibility of a partial antagonism of salicylate to AVT at the renal level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames E., Steven K., Skadhauge E. Effects of arginine vasotocin on renal excretion of Na+, K+, Cl-, and urea in the hydrated chicken. Am J Physiol. 1971 Nov;221(5):1223–1228. doi: 10.1152/ajplegacy.1971.221.5.1223. [DOI] [PubMed] [Google Scholar]
  2. Anderson R. J., Berl T., McDonald K. D., Schrier R. W. Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney. J Clin Invest. 1975 Aug;56(2):420–426. doi: 10.1172/JCI108108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berg K. J. Acute effects of acetylsalicylic acid on renal function in normal man. Eur J Clin Pharmacol. 1977 Jan 3;11(2):117–123. doi: 10.1007/BF00562902. [DOI] [PubMed] [Google Scholar]
  4. Berg K. J., Bergan A. Effects of different doses of acetylsalicylic acid on renal function in the dog. Scand J Clin Lab Invest. 1976 Dec;36(8):779–786. doi: 10.3109/00365517609081937. [DOI] [PubMed] [Google Scholar]
  5. Berl T., Raz A., Wald H., Horowitz J., Czaczkes W. Prostaglandin synthesis inhibition and the action of vasopressin: studies in man and rat. Am J Physiol. 1977 Jun;232(6):F529–F537. doi: 10.1152/ajprenal.1977.232.6.F529. [DOI] [PubMed] [Google Scholar]
  6. Bisordi J. E., Schlondorff D., Hays R. M. Interaction of vasopressin and prostaglandins in the toad urinary bladder. J Clin Invest. 1980 Dec;66(6):1200–1210. doi: 10.1172/JCI109971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fejes-Tóth G., Magyar A., Walter J. Renal response to vasopressin after inhibition of prostaglandin synthesis. Am J Physiol. 1977 May;232(5):F416–F423. doi: 10.1152/ajprenal.1977.232.5.F416. [DOI] [PubMed] [Google Scholar]
  8. Flower R. J. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974 Mar;26(1):33–67. [PubMed] [Google Scholar]
  9. GARDIER R. W., STEEN R., RICHARDS A. B. Water and electrolyte pharmacodynamics of aspirin. Proc Soc Exp Biol Med. 1962 Apr;109:824–826. doi: 10.3181/00379727-109-27347. [DOI] [PubMed] [Google Scholar]
  10. Kirschenbaum M. A., Stein J. H. The effect of inhibition of prostaglandin synthesis on urinary sodium excretion in the conscious dog. J Clin Invest. 1976 Feb;57(2):517–521. doi: 10.1172/JCI108304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Möhring J., Schoun J., Simon-Oppermann C., Simon E. Radioimmunoassay for arginine-vasotocin (AVT) in serum of Pekin ducks: AVT concentrations after adaptation to fresh water and salt water. Pflugers Arch. 1980 Sep;387(2):91–97. doi: 10.1007/BF00584258. [DOI] [PubMed] [Google Scholar]
  12. O'Dea K., Pütter J., Hoffmeister F. Antinociceptive action and plasma levels of acetylsalicylic acid in the dog. Arzneimittelforschung. 1975 May;25(5):801–806. [PubMed] [Google Scholar]
  13. Quintanilla A., Kessler R. H. Direct effects of salicylate on renal function in the dog. J Clin Invest. 1973 Dec;52(12):3143–3153. doi: 10.1172/JCI107514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ramsay A. G., Elliott H. C. Effect of acetylsalicylic acid on ionic reabsorption in the renal tubule. Am J Physiol. 1967 Aug;213(2):323–327. doi: 10.1152/ajplegacy.1967.213.2.323. [DOI] [PubMed] [Google Scholar]
  15. Schlondorff D., Carvounis C. P., Jacoby M., Satriano J. A., Levine S. D. Multiple sites for interaction of prostaglandin and vasopressin in toad urinary bladder. Am J Physiol. 1981 Dec;241(6):F625–F631. doi: 10.1152/ajprenal.1981.241.6.F625. [DOI] [PubMed] [Google Scholar]
  16. Simon-Oppermann C., Hammel H. T., Simon E. Hypothalamic temperature and osmoregulation in the Pekin duck. Pflugers Arch. 1979 Jan 31;378(3):213–221. doi: 10.1007/BF00592738. [DOI] [PubMed] [Google Scholar]
  17. Simon E. The osmoregulatory system of birds with salt glands. Comp Biochem Physiol A Comp Physiol. 1982;71(4):547–556. doi: 10.1016/0300-9629(82)90203-1. [DOI] [PubMed] [Google Scholar]
  18. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]

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