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. 1984 Sep;83(1):83–88. doi: 10.1111/j.1476-5381.1984.tb10122.x

Some characteristics of the long-latency component of the evoked muscle response induced by administration of catechol to the anaesthetized rat: a neurophysiological and neuropharmacological investigation.

D G Dewhurst
PMCID: PMC1987175  PMID: 6091830

Abstract

Administration of catechol to rats anaesthetized with urethane produces a central excitatory state during which an EMG consisting of three temporally distinct components (M1, M2 and M3) can be recorded from forelimb and hindlimb muscles to electrical stimulation of cutaneous afferents. The probability of occurrence of all three components was measured in flexor and extensor muscles of fore- and hindlimb and showed that the long latency component (M3) occurred less frequently in hindlimb muscles than forelimb and that its probability of occurrence in hindlimb extensors was significantly reduced as compared to flexors. A possible reflex pathway for this long latency component of the EMG is suggested. Phenobarbitone (5 mg kg-1 i.v.) had no significant effect on the probability of occurrence of M1, M2 or M3. These results suggest that the long latency component (M3) is not due to activation of a spino-bulbo-spinal reflex as has been previously suggested. Cholinoceptor blocking drugs were found to reduce significantly the probability of occurrence of M2 and M3 and anticholinesterases to increase the probability of M2. None of the drugs was found to affect the short latency M1 component of the EMG. These results are discussed in relation to the possible reflex pathways of all three components of the EMG.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angel A., Clarke K. A., Dewhurst D. G. A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse. Br J Pharmacol. 1977 Nov;61(3):433–439. doi: 10.1111/j.1476-5381.1977.tb08437.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Angel A., Dewhurst D. G. A pharmacological investigation of the electrically evoked convulsive activity induced by administration of catechol in the anaesthetized rat. Br J Pharmacol. 1978 Dec;64(4):539–544. doi: 10.1111/j.1476-5381.1978.tb17315.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Angel A., Lemon R. N. An analysis of the myoclonic jerks produced by 1, 2-dihydroxybenzene in the rat. Electroencephalogr Clin Neurophysiol. 1973 Dec;35(6):589–601. doi: 10.1016/0013-4694(73)90212-5. [DOI] [PubMed] [Google Scholar]
  4. Angel A., Lemon R. N. Sensorimotor cortical representation in the rat and the role of the cortex in the production of sensory myoclonic jerks. J Physiol. 1975 Jun;248(2):465–488. doi: 10.1113/jphysiol.1975.sp010984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Angel A., Lemon R. N. The convulsive action of 1,2-dihydroxybenzene in the anaesthetized rat. Electroencephalogr Clin Neurophysiol. 1973 Apr;34(4):369–378. doi: 10.1016/0013-4694(73)90088-6. [DOI] [PubMed] [Google Scholar]
  6. Gallagher J. P., Blaber L. C. Catechol, a facilitatory drug that demonstrates only a prejunctional site of action. J Pharmacol Exp Ther. 1973 Jan;184(1):129–135. [PubMed] [Google Scholar]
  7. Gardner C. R., Webster R. A. Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. Eur J Pharmacol. 1977 Apr 7;42(3):247–256. doi: 10.1016/0014-2999(77)90291-6. [DOI] [PubMed] [Google Scholar]
  8. Hemsworth B. A., Neal M. J. The effect of central stimulant drugs on acetylcholine release from rat cerebral cortex. Br J Pharmacol. 1968 Nov;34(3):543–550. doi: 10.1111/j.1476-5381.1968.tb08483.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lundy P. M., Shaw R. K. Modification of cholinergically induced convulsive activity and cyclic GMP levels in the CNS. Neuropharmacology. 1983 Jan;22(1):55–63. doi: 10.1016/0028-3908(83)90260-5. [DOI] [PubMed] [Google Scholar]
  10. Rastogi S. K., Puri J. N., Sinha J. N., Bhargava K. P. Involvement of central cholinoceptors in Metrazol-induced convulsions. Psychopharmacology (Berl) 1979 Oct;65(2):215–217. doi: 10.1007/BF00433052. [DOI] [PubMed] [Google Scholar]
  11. SHIMAMURA M., LIVINGSTON R. B. Longitudinal conduction systems serving spinal and brain-stem coordination. J Neurophysiol. 1963 Mar;26:258–272. doi: 10.1152/jn.1963.26.2.258. [DOI] [PubMed] [Google Scholar]
  12. Shimamura M., Mori S., Yamauchi T. Effects of spino-bulbo-spinal reflex volleys on extensor motoneurons of hindlimb in cats. J Neurophysiol. 1967 Mar;30(2):319–332. doi: 10.1152/jn.1967.30.2.319. [DOI] [PubMed] [Google Scholar]
  13. Shimamura M. Spino-bulbo-spinal and propriospinal reflexes in various vertebrates. Brain Res. 1973 Dec 21;64:141–165. doi: 10.1016/0006-8993(73)90175-3. [DOI] [PubMed] [Google Scholar]

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