Abstract
Initiation of 60 min ischaemia to rat isolated hearts produced a depression in developed tension and heart rate. Subsequent reperfusion caused a greatly exacerbated creatine phosphokinase (CPK) efflux and limited functional recovery. Sulphinpyrazone (100 ng ml-1 and 1 microgram ml-1) significantly reduced CPK release, particularly after reperfusion, the lower concentration being more effective. A reduction in the mechanical depression during ischaemia and enhanced recovery after reperfusion were seen only with 100 ng ml-1 sulphinpyrazone. Heart rate and coronary perfusion pressure were unaffected by drug treatment. The reduction in reperfusion-induced CPK efflux by 100 ng ml-1 sulphinpyrazone was maximal when the drug was present throughout the perfusion period although some protection was evident when sulphinpyrazone was present either during ischaemia or reperfusion only. An enhanced recovery in contractility was seen only when the drug was present throughout all phases of perfusion. It is suggested that sulphinpyrazone exerts a direct protective effect on the heart particularly during reperfusion. The degree of protection is critically dependent on the concentration of sulphinpyrazone.
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Selected References
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- Ali M., McDonald J. W. Effects of sulfinpyrazone on platelet prostaglandin synthesis and platelet release of serotonin. J Lab Clin Med. 1977 Apr;89(4):868–875. [PubMed] [Google Scholar]
- Beamish R. E., Dhillon K. S., Singal P. K., Dhalla N. S. Protective effect of sulfinpyrazone against catecholamine metabolite adrenochrome-induced arrhythmias. Am Heart J. 1981 Aug;102(2):149–152. doi: 10.1016/s0002-8703(81)80001-4. [DOI] [PubMed] [Google Scholar]
- Bolli R., Goldstein R. E., Davenport N., Epstein S. E. Influence of sulfinpyrazone and naproxen on infarct size in the dog. Am J Cardiol. 1981 Apr;47(4):841–847. doi: 10.1016/0002-9149(81)90183-1. [DOI] [PubMed] [Google Scholar]
- Brunner L., Stepanek J., Brunner H. Reduction of mortality by sulphinpyrazone after experimental myocardial infarction in the rat. J Pharm Pharmacol. 1980 Oct;32(10):714–715. doi: 10.1111/j.2042-7158.1980.tb13047.x. [DOI] [PubMed] [Google Scholar]
- Davenport N., Goldstein R. E., Capurro N., Lipson L. C., Bonow R. O., Shulman N. R., Epstein S. E. Sulfinpyrazone and aspirin increase epicardial coronary collateral flow in dogs. Am J Cardiol. 1981 Apr;47(4):848–854. doi: 10.1016/0002-9149(81)90184-3. [DOI] [PubMed] [Google Scholar]
- Digerness S. B., Shragge B. W., Blackstone E. H., Conti V. R. Temperature dependence of the calcium paradox in the isolated working rat heart: discrepancy between functional recovery and enzyme release. J Mol Cell Cardiol. 1980 May;12(5):511–517. doi: 10.1016/0022-2828(80)90007-3. [DOI] [PubMed] [Google Scholar]
- Hearse D. J. Reperfusion of the ischemic myocardium. J Mol Cell Cardiol. 1977 Aug;9(8):605–616. doi: 10.1016/s0022-2828(77)80357-x. [DOI] [PubMed] [Google Scholar]
- Innes I. R., Weisman H. Reduction in the severity of myocardial infarction by sulfinpyrazone. Am Heart J. 1981 Aug;102(2):153–157. doi: 10.1016/s0002-8703(81)80002-6. [DOI] [PubMed] [Google Scholar]
- Karmazyn M., Beamish R. E., Fliegel L., Dhalla N. S. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219(1):225–230. [PubMed] [Google Scholar]
- Karmazyn M., Moffat M. P., Beamish R. E., Dhalla N. S. Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage. J Pharmacol Exp Ther. 1981 Sep;218(3):764–770. [PubMed] [Google Scholar]
- Maguire E. D., Pay G. F., Turney J., Wallis R. B., Weston M. J., White A. M., Williams L. C., Woods H. F. The effects of two different dosage regimens of sulphinpyrazone on platelet function ex vivo and blood chemistry in man. Haemostasis. 1981;10(3):153–164. doi: 10.1159/000214399. [DOI] [PubMed] [Google Scholar]
- SMYTHE H. A., OGRYZLO M. A., MURPHY E. A., MUSTARD J. F. THE EFFECT OF SULFINPYRAZONE (ANTURAN) ON PLATELET ECONOMY AND BLOOD COAGULATION IN MAN. Can Med Assoc J. 1965 Apr 10;92:818–821. [PMC free article] [PubMed] [Google Scholar]