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. 1984 May;82(1):233–239. doi: 10.1111/j.1476-5381.1984.tb16463.x

Some effects of nicotine on food and water intake in undeprived rats.

P B Clarke, R Kumar
PMCID: PMC1987251  PMID: 6539631

Abstract

Undeprived rats were tested in their home cages for intake of water and powered food, starting 15 min after subcutaneous (s.c.) injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). In the first 2 h, nicotine (0-0.4 mg kg-1 base) markedly reduced water intake in a dose-related way, leaving food intake unchanged. Food and water intake up to 24 h after injection was unaffected. Rats (n = 6 per group) were then injected daily with nicotine (0.4 mg kg-1 base, s.c.) or saline for one month. Intermittent tests with saline (in place of nicotine) during this period did not reveal any signs of abstinence. A dose-response study similar to the first was then carried out, and little or no tolerance was found to the hypodipsic action of nicotine. Nicotine also reduced food intake, irrespective of chronic treatment. Subsequently, daily injections were discontinued, and spontaneous intake did not differ in rats previously maintained on nicotine, relative to control animals. Mecamylamine (0.3, 1.5 mg kg-1, s.c.) prevented nicotine-induced hypodipsia, whereas chlorisondamine (0.02, 0.1 mg kg-1 s.c.) was ineffective. Both ganglion blockers reduced food intake. Nicotine did not reduce drinking in rats preloaded with a hypertonic saline solution. It is suggested that nicotine reduces water intake in undeprived rats, probably by acting centrally. Since this action changes little with repeated testing, it may provide a useful index of one or more central actions of the drug.

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Selected References

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  1. Ascher P., Large W. A., Rang H. P. Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells. J Physiol. 1979 Oct;295:139–170. doi: 10.1113/jphysiol.1979.sp012958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baettig K., Martin J. R., Classen W. Nicotine and amphetamine: differential tolerance and no cross-tolerance for ingestive effects. Pharmacol Biochem Behav. 1980 Jan;12(1):107–111. doi: 10.1016/0091-3057(80)90423-2. [DOI] [PubMed] [Google Scholar]
  3. Beckett A. H., Gorrod J. W., Jenner P. The effect of smoking on nicotine metabolism in vivo in man. J Pharm Pharmacol. 1971 Dec;23:62S–67S. doi: 10.1111/j.2042-7158.1971.tb08770.x. [DOI] [PubMed] [Google Scholar]
  4. Bisset G. W., Feldberg W. Effect of hexamethonium on the release of vasopressin by nicotine and carotid occlusion [proceedings]. J Physiol. 1977 May;267(1):30P–31P. [PubMed] [Google Scholar]
  5. Clarke P. B., Kumar R. Characterization of the locomotor stimulant action of nicotine in tolerant rats. Br J Pharmacol. 1983 Nov;80(3):587–594. doi: 10.1111/j.1476-5381.1983.tb10733.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clarke P. B., Kumar R. Nicotine does not improve discrimination of brain stimulation reward by rats. Psychopharmacology (Berl) 1983;79(2-3):271–277. doi: 10.1007/BF00427826. [DOI] [PubMed] [Google Scholar]
  7. Clarke P. B., Kumar R. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br J Pharmacol. 1983 Feb;78(2):329–337. doi: 10.1111/j.1476-5381.1983.tb09398.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DE WIED D., JINKS R. Effect of chlorpromazine on antidiuretic response to noxious stimuli. Proc Soc Exp Biol Med. 1958 Oct;99(1):44–45. doi: 10.3181/00379727-99-24241. [DOI] [PubMed] [Google Scholar]
  9. Glick S. D., Greenstein S. Pharmacological inhibition of eating, drinking and prandial drinking. Behav Biol. 1973 Jan;8(1):55–61. doi: 10.1016/s0091-6773(73)80006-9. [DOI] [PubMed] [Google Scholar]
  10. Hall G. H., Morrison C. F. New evidence for a relationship between tobacco smoking, nicotine dependence and stress. Nature. 1973 May 25;243(5404):199–201. doi: 10.1038/243199a0. [DOI] [PubMed] [Google Scholar]
  11. LAFFAN R. J., BORISON H. L. Emetic action of nicotine and lobeline. J Pharmacol Exp Ther. 1957 Dec;121(4):468–476. [PubMed] [Google Scholar]
  12. Mansner R., Mattila M. J. Nicotine induced tremor and antidiuresis and brain nicotine levels in the rat. Med Biol. 1975 Jun;53(3):169–176. [PubMed] [Google Scholar]
  13. Morrison C. F., Goodyear J. M., Sellers C. M. Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine. Psychopharmacologia. 1969;15(5):341–350. doi: 10.1007/BF00403709. [DOI] [PubMed] [Google Scholar]
  14. Münster G., Bättig K. Nicotine-induced hypophagia and hypodipsia in deprived and in hypothalamically stimulated rats. Psychopharmacologia. 1975;41(3):211–217. doi: 10.1007/BF00428926. [DOI] [PubMed] [Google Scholar]
  15. PLUMMER A. J., TRAPOLD J. H., SCHNEIDER J. A., MAXWELL R. A., EARL A. E. Ganglionic blockade by a new bisquaternary series, including chlorisondamine dimethochloride. J Pharmacol Exp Ther. 1955 Oct;115(2):172–184. [PubMed] [Google Scholar]
  16. Romano C., Goldstein A. Stereospecific nicotine receptors on rat brain membranes. Science. 1980 Nov 7;210(4470):647–650. doi: 10.1126/science.7433991. [DOI] [PubMed] [Google Scholar]
  17. STONE C. A., MECKELNBURG K. L., TORCHIANA M. L. Antagonism of nicotine-induced convulsions by ganglionic blocking agents. Arch Int Pharmacodyn Ther. 1958 Nov-Dec;117(3-4):419–434. [PubMed] [Google Scholar]
  18. Sanger D. J. Nicotine and schedule-induced drinking in rats. Pharmacol Biochem Behav. 1978 Apr;8(4):343–346. doi: 10.1016/0091-3057(78)90068-0. [DOI] [PubMed] [Google Scholar]
  19. Schechter M. D., Cook P. G. Nicotine-induced weight loss in rats without an effect on appetite. Eur J Pharmacol. 1976 Jul;38(1):63–69. doi: 10.1016/0014-2999(76)90201-6. [DOI] [PubMed] [Google Scholar]
  20. Sladek C. D., Joynt R. J. Characterization of cholinergic control of vasopressin release by the organ-cultured rat hypothalamo-neurohypophyseal system. Endocrinology. 1979 Mar;104(3):659–663. doi: 10.1210/endo-104-3-659. [DOI] [PubMed] [Google Scholar]
  21. Stitzer M., Morrison J., Domino E. F. Effects of nicotine on fixed-interval behavior and their modification by cholinergic antagonists. J Pharmacol Exp Ther. 1970 Feb;171(2):166–177. [PubMed] [Google Scholar]

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