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. 1969 Aug 9;3(5666):330, 331-332. doi: 10.1136/bmj.3.5666.330

Failure of Intravenous Aspirin to Increase Gastrointestinal Blood Loss

Allan R Cooke, Kerry Goulston
PMCID: PMC1989048  PMID: 5306445

Abstract

Studies of the effect of intravenous sodium acetylsalicylate (aspirin) on gastrointestinal blood loss with 51Cr-labelled red cells were made on 15 healthy male volunteers. After a control period of five days 1 g. of sodium acetylsalicylate was infused over a period of 100 minutes twice daily for three days. Faecal blood loss was not increased.

In a further six subjects 3 g. of sodium acetylsalicylate was infused over a period of 120 minutes. No salicylate or acetylsalicylate was detected in saliva or gastric washings from these six subjects. Hence gastrointestinal blood loss induced by aspirin may be explained by a local effect on mucosa and not by any systemic effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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