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. 1968 Sep 21;3(5620):710–713. doi: 10.1136/bmj.3.5620.710

Occurrence of Goitre during Lithium Treatment

M Schou, A Amdisen, S Eskjær Jensen, T Olsen
PMCID: PMC1989588  PMID: 17016877

Abstract

Of 330 patients given lithium for recurrent manic-depressive disorder 12 developed goitre after treatment periods of five months to two years. All the patients remained clinically euthyroid. Pressure symptoms necessitated subtotal thyroidectomy in two patients. In 9 out of 10 patients with goitre, and in two out of seven without goitre study with radioactive iodine showed abnormal findings in iodine metabolism. Discontinuance of lithium led to disappearance of goitres, while thyroid metabolism returned to normal. Thyroxine or desiccated thyroid produced shrinkage of the gland in spite of continued lithium medication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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