Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1968 Aug 10;3(5614):352–355. doi: 10.1136/bmj.3.5614.352

Experience With a Hepatitis-free Plasma Protein Solution

A J Salsbury, M Brozovich
PMCID: PMC1991203  PMID: 5662990

Abstract

Clinical experience with a 4.3% solution of plasma protein treated to render it free of the agent of serum hepatitis is satisfactory. Sixty-seven transfusions of 400 ml. of the commercial preparation were given to 33 patients (25 with acute blood loss, 4 with severe burns, and 4 with hypoproteinaemia secondary to hepatic or renal disease).

The solution was clinically as effective as reconstituted dried plasma in expanding plasma volume and in replacing serum protein lost in burns. Adverse effects were mild pyrexial reactions in one case and facial flushing in another. No cases of serum hepatitis occurred.

The solution is available for immediate use, it can be kept at room temperature, and, as it does not cause rouleaux formation, it can be given before blood is taken for grouping and cross-matching.

Full text

PDF
352

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUERSWALD W., DOLESCHEL W. Fünfjährige Erfahrung mit einer hitze-inaktivierten stabilisierten Plasmaproteinlösung. Bibl Haematol. 1959;9:61–63. [PubMed] [Google Scholar]
  2. AUERSWALD W., EIBL H. Vergleich des Verhaltens verschiedener humaner Plasmaproteinlösungen bei der Hitze-Virusinaktivierung. Wien Med Wochenschr. 1955 Apr 16;105(15):298–299. [PubMed] [Google Scholar]
  3. DAMESHEK W., NEBER J. Transfusion reactions to plasma constituent of whole blood; their pathogenesis and treatment by washed red blood cell transfusions. Blood. 1950 Feb;5(2):129–147. [PubMed] [Google Scholar]
  4. DYKES P. W. A study of the effects of albumin infusions in patients with cirrhosis of the liver. Q J Med. 1961 Jul;30:297–327. [PubMed] [Google Scholar]
  5. HILLMAN R. S. POOLED HUMAN PLASMA AS A VOLUME EXPANDER. N Engl J Med. 1964 Nov 12;271:1027–1032. doi: 10.1056/NEJM196411122712002. [DOI] [PubMed] [Google Scholar]
  6. HUTCHISON J. L., FREEDMAN S. O., RICHARDS B. A., BURGE A. S. Plasma volume expansion and reactions after infusion of autologous and nonautologous plasma in man. J Lab Clin Med. 1960 Nov;56:734–746. [PubMed] [Google Scholar]
  7. LEHANE D., KWANTES C. M. S. Homologous serum jaundice. Br Med J. 1949 Sep 10;2(4627):572–574. doi: 10.1136/bmj.2.4627.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MURRAY R., DIEFENBACH W. C. Effect of heat on the agent of homologous serum hepatitis. Proc Soc Exp Biol Med. 1953 Oct;84(1):230–231. doi: 10.3181/00379727-84-20599. [DOI] [PubMed] [Google Scholar]
  9. MURRAY R., DIEFENBACH W. C., GELLER H., LEONE N. C., RATNER F. The problem of reducing the danger of serum; hepatitis from blood and blood products. N Y State J Med. 1955 Apr 15;55(8):1145–1160. [PubMed] [Google Scholar]
  10. PAINE R. S., JANEWAY C. A. Human albumin infusions and homologous serum jaundice. J Am Med Assoc. 1952 Sep 20;150(3):199–202. doi: 10.1001/jama.1952.03680030031009. [DOI] [PubMed] [Google Scholar]
  11. STEPHEN C. R., MARTIN R. C., BOURGEOIS-GAVARDIN M. Antihistaminic drugs in treatment of nonhemolytic transfusion reactions. J Am Med Assoc. 1955 Jun 18;158(7):525–529. doi: 10.1001/jama.1955.02960070001001. [DOI] [PubMed] [Google Scholar]
  12. Salsbury A. J. Effect of transfusion materials on rouleaux formation and sedimentation rate of erythrocytes. Br Med J. 1967 Oct 14;4(5571):88–90. doi: 10.1136/bmj.4.5571.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WILKINSON P., SHERLOCK S. The effect of repeated albumin infusions in patients with cirrhosis. Lancet. 1962 Dec 1;2(7266):1125–1129. doi: 10.1016/s0140-6736(62)90895-4. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES