Fig. 5.

Disruption of FBG/fibrin-integrin binding decreases neurite growth in fibrin. A, Mouse spinal cord neurons were embedded in salmon fibrin with and without an integrin inhibitor, echistatin, for 3 days (arrows denote neuronal cell bodies and ends of neurites). Scale bar is 50 μm. B, Quantification of neurite growth of mouse spinal cord neurons after 2 days in FN-free salmon fibrin or bovine fibrin with and without echistatin (**p<0.001 echistatin-treated vs. non-treated controls, error bars represent s.e.m.).