Table 1 Risk of gastric adenocarcinoma for Helicobacter pylori serostatus, quintiles of serum pepsinogen I:II and quintiles of serum gastrin concentration according to different gastric subsites and adenocarcinoma subtypes.
| Risk factor | Cardia (44 cases, 132 controls) | Non‐cardia overall (129 cases, 376 controls)* | Non‐cardia, intestinal (59 cases, 173 controls) | Non‐cardia, diffuse (35 cases, 100 controls) | Non‐cardia, mixed (31 cases, 91 controls) |
|---|---|---|---|---|---|
| H pylori serostatus | |||||
| Negative | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Positive | 0.27 (0.12 to 0.59) | 4.75 (2.56 to 8.81) | 3.96 (1.69 to 9.27) | 3.90 (1.11 to 13.7) | 5.51 (1.52 to 20.0) |
| p Value | 0.001 | <0.005 | 0.002 | 0.034 | 0.010 |
| Serum pepsinogen I:II quintiles | |||||
| 5th 6.060–30.973 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 4th 4.803–6.055 | 0.24 (0.07 to 0.75) | 1.21 (0.48 to 3.05) | 1.07 (0.30 to 3.74) | 0.31 (0.03 to 3.33) | 4.35 (0.44 to 43.4) |
| 3rd 3.777–4.795 | 0.68 (0.27 to 1.74) | 2.49 (1.07 to 5.78) | 1.50 (0.47 to 4.82) | 2.02 (0.46 to 8.86) | 13.4 (1.20 to 150) |
| 2nd 2.691–3.774 | 0.14 (0.03 to 0.71) | 5.35 (2.35 to 12.2) | 2.96 (0.94 to 9.29) | 7.82 (1.87 to 32.6) | 14.6 (1.35 to 157) |
| 1st 0.323–2.688 | 0.78 (0.26 to 2.39) | 11.6 (4.91 to 27.5) | 12.5 (3.57 to 43.9) | 6.29 (1.45 to 27.3) | 24.9 (2.28 to 272) |
| p Value for trend | 0.391 | <0.005 | <0.005 | <0.005 | 0.002 |
| Serum gastrin quintiles (ng/l) | |||||
| 1st 2–20 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 2nd 25–30 | 1.25 (0.44 to 3.55) | 1.99 (0.82 to 4.83) | 1.56 (0.44 to 5.52) | 8.19 (0.80 to 84.2) | 1.75 (0.30 to 10.2) |
| 3rd 35–55 | 1.58 (0.58 to 4.28) | 2.45 (1.13 to 5.35) | 1.82 (0.59 to 5.58) | 10.6 (1.13 to 99.0) | 1.66 (0.37 to 7.41) |
| 4th 60–90 | 0.71 (0.19 to 2.66) | 3.82 (1.77 to 8.23) | 3.66 (1.23 to 10.9) | 8.42 (0.97 to 73.2) | 3.44 (0.82 to 14.5) |
| 5th 95–462 | 1.63 (0.48 to 5.48) | 8.99 (3.96 to 20.4) | 12.8 (3.83 to 42.6) | 21.8 (2.29 to 208) | 3.68 (0.77 to 17.7) |
| p Value for trend | 0.702 | <0.005 | <0.005 | 0.007 | 0.042 |
Values are represented as OR (95% CI).
*Including four histologically unclassifiable cases and 12 corresponding controls.