Abstract
Female SJL/N mice were exposed to mercury vapour 5 days/week for 10 weeks, at a mercury concentration of approximately 0.5 mg/m3, 19 h/day; 1 mg/m3, 3 h/day; 0.3 mg/m3, 6 h/day or 1 mg/m3, 1.5 h/day. The total mercury concentrations in the brain were 6.4, 6.3, 1.6 and 0.64 micrograms/g tissue, respectively. The mercury distribution in the brains was examined. Mercury was found in almost the whole brain in the two groups with the highest exposure. In the third group, mercury was primarily found in the neocortical layer V, the white matter, thalamus, and the brain-stem. In the fourth group, the white matter and the brain-stem were the targets for mercury accumulation. Similarities and differences between rats and mice in the distribution pattern are discussed.
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- Danscher G., Møller-Madsen B. Silver amplification of mercury sulfide and selenide: a histochemical method for light and electron microscopic localization of mercury in tissue. J Histochem Cytochem. 1985 Mar;33(3):219–228. doi: 10.1177/33.3.2579122. [DOI] [PubMed] [Google Scholar]
- Fowler B. A., Brown H. W., Lucier G. W., Beard M. E. Mercury uptake by renal lysosomes of rats ingesting methyl mercury hydroxide. Ultrastructural observations and energy dispersive x-ray analysis. Arch Pathol. 1974 Nov;98(5):297–301. [PubMed] [Google Scholar]
- Hua J., Pelletier L., Berlin M., Druet P. Autoimmune glomerulonephritis induced by mercury vapour exposure in the Brown Norway rat. Toxicology. 1993 Apr 30;79(2):119–129. doi: 10.1016/0300-483x(93)90125-c. [DOI] [PubMed] [Google Scholar]
- Hultman P., Eneström S. Mercury induced B-cell activation and antinuclear antibodies in mice. J Clin Lab Immunol. 1989 Mar;28(3):143–150. [PubMed] [Google Scholar]
- Hursh J. B., Cherian M. G., Clarkson T. W., Vostal J. J., Mallie R. V. Clearance of mercury (HG-197, HG-203) vapor inhaled by human subjects. Arch Environ Health. 1976 Nov-Dec;31(6):302–309. doi: 10.1080/00039896.1976.10667240. [DOI] [PubMed] [Google Scholar]
- Møller-Madsen B., Danscher G. Localization of mercury in CNS of the rat. I. Mercuric chloride (HgCl2) per os. Environ Res. 1986 Oct;41(1):29–43. doi: 10.1016/s0013-9351(86)80165-7. [DOI] [PubMed] [Google Scholar]
- Møller-Madsen B., Danscher G. Localization of mercury in CNS of the rat. IV. The effect of selenium on orally administered organic and inorganic mercury. Toxicol Appl Pharmacol. 1991 May;108(3):457–473. doi: 10.1016/0041-008x(91)90092-s. [DOI] [PubMed] [Google Scholar]
- Møller-Madsen B., Dinesen J., Simonsen O., Christensen S. T., Nielsen F. F., Barfod E., Sommer J. Skoleulykker i Arhus kommune 1982-1983. III. Frikvartersulykker. Ugeskr Laeger. 1986 Jul 28;148(31):1991–1994. [PubMed] [Google Scholar]
- Møller-Madsen B. Localization of mercury in CNS of the rat. II. Intraperitoneal injection of methylmercuric chloride (CH3HgCl) and mercuric chloride (HgCl2). Toxicol Appl Pharmacol. 1990 Apr;103(2):303–323. doi: 10.1016/0041-008x(90)90232-j. [DOI] [PubMed] [Google Scholar]
- Møller-Madsen B. Localization of mercury in CNS of the rat. III. Oral administration of methylmercuric chloride (CH3HgCl). Fundam Appl Toxicol. 1991 Jan;16(1):172–187. [PubMed] [Google Scholar]
- Møller-Madsen B. Localization of mercury in CNS of the rat. V. Inhalation exposure to metallic mercury. Arch Toxicol. 1992;66(2):79–89. doi: 10.1007/BF02342499. [DOI] [PubMed] [Google Scholar]
- Schiønning J., Møller-Madsen B. Autometallographic mapping of mercury deposits in the spinal cord of rats treated with inorganic mercury. Acta Neuropathol. 1991;81(4):434–442. doi: 10.1007/BF00293465. [DOI] [PubMed] [Google Scholar]
- Warfvinge K., Hua J., Berlin M. Mercury distribution in the rat brain after mercury vapor exposure. Toxicol Appl Pharmacol. 1992 Nov;117(1):46–52. doi: 10.1016/0041-008x(92)90215-e. [DOI] [PubMed] [Google Scholar]