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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1995 Dec;76(6):403–409.

Prevention of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice by treatment with antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1.

T Hayashi 1, S Yamamoto 1, T Onodera 1
PMCID: PMC1997205  PMID: 8652360

Abstract

Reovirus type 2-induced diabetes-like syndrome in suckling mice is considered to be an animal model for human insulin-dependent diabetes mellitus. We have previously demonstrated that immunopathologic pancreatic islet cell damage might be relevant to reovirus type 2 infection. In this study the involvement of adhesion molecules in the development of reovirus type 2-induced diabetes-like syndrome was examined. In infected mice infiltration of mononuclear cells mixed with polymorphonuclear leucocytes in and around pancreatic islets (insulitis) was observed in association with abnormal glucose tolerance. The treatment with monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) prevented the development of insulitis with abnormal glucose tolerance in a dose dependent manner. These results suggest that ICAM-1 and LFA-1 molecules may, at least in part, participate in islet cell damage, resulting in reovirus type 2-induced diabetes-like syndrome. The role of ICAM-1 and LFA-1 molecules on the development of insulitis is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Campbell I. L., Cutri A., Wilkinson D., Boyd A. W., Harrison L. C. Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4282–4286. doi: 10.1073/pnas.86.11.4282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Campbell I. L., Harrison L. C. A new view of the beta cell as an antigen-presenting cell and immunogenic target. J Autoimmun. 1990 Apr;3 (Suppl 1):53–62. doi: 10.1016/s0896-8411(09)90010-5. [DOI] [PubMed] [Google Scholar]
  3. Diamond M. S., Staunton D. E., Marlin S. D., Springer T. A. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell. 1991 Jun 14;65(6):961–971. doi: 10.1016/0092-8674(91)90548-d. [DOI] [PubMed] [Google Scholar]
  4. Faveeuw C., Gagnerault M. C., Lepault F. Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J Immunol. 1994 Jun 15;152(12):5969–5978. [PubMed] [Google Scholar]
  5. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965 Oct;14(10):619–633. doi: 10.2337/diab.14.10.619. [DOI] [PubMed] [Google Scholar]
  6. Hayashi T., Hashimoto S., Kameyama Y. Reduced streptozotocin-induced insulitis in CD-1 mice by treatment with anti-intercellular adhesion molecule-1 and anti-lymphocyte function associated antigen-1 monoclonal antibodies together with lactic dehydrogenase virus infection. Int J Exp Pathol. 1994 Apr;75(2):117–121. [PMC free article] [PubMed] [Google Scholar]
  7. Hayashi T., Hashimoto S., Kawashima A. Effect of infection by lactic dehydrogenase virus on expression of intercellular adhesion molecule-1 on vascular endothelial cells of pancreatic islets in streptozotocin-induced insulitis of CD-1 mice. Int J Exp Pathol. 1994 Jun;75(3):211–217. [PMC free article] [PubMed] [Google Scholar]
  8. Hänninen A., Jalkanen S., Salmi M., Toikkanen S., Nikolakaros G., Simell O. Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest. 1992 Nov;90(5):1901–1910. doi: 10.1172/JCI116067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Isobe M., Yagita H., Okumura K., Ihara A. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science. 1992 Feb 28;255(5048):1125–1127. doi: 10.1126/science.1347662. [DOI] [PubMed] [Google Scholar]
  10. Itoh N., Hanafusa T., Miyazaki A., Miyagawa J., Yamagata K., Yamamoto K., Waguri M., Imagawa A., Tamura S., Inada M. Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest. 1993 Nov;92(5):2313–2322. doi: 10.1172/JCI116835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jenson A. B., Rosenberg H. S., Notkins A. L. Pancreatic islet-cell damage in children with fatal viral infections. Lancet. 1980 Aug 16;2(8190):354–358. [PubMed] [Google Scholar]
  12. Kurogi H., Inaba Y., Takahashi E., Sato K., Omori T. Serological relationship between Japanese strains of reovirus of bovine origin and type 2 reovirus strains. Natl Inst Anim Health Q (Tokyo) 1980 Spring;20(1):32–33. [PubMed] [Google Scholar]
  13. Makino S., Kunimoto K., Muraoka Y., Mizushima Y., Katagiri K., Tochino Y. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu. 1980 Jan;29(1):1–13. doi: 10.1538/expanim1978.29.1_1. [DOI] [PubMed] [Google Scholar]
  14. Notkins A. L. Virus-induced diabetes mellitus. Arch Virol. 1977;54(1-2):1–17. doi: 10.1007/BF01314374. [DOI] [PubMed] [Google Scholar]
  15. Onodera T., Jenson A. B., Yoon J. W., Notkins A. L. Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice. Science. 1978 Aug 11;201(4355):529–531. doi: 10.1126/science.208156. [DOI] [PubMed] [Google Scholar]
  16. Onodera T., Taniguchi T., Tsuda T., Yoshihara K., Shimizu S., Sato M., Awaya A., Hayashi T. Thymic atrophy in type 2 reovirus infected mice: immunosuppression and effects of thymic hormone. Thymic atrophy caused by reo-2. Thymus. 1991 Sep;18(2):95–109. [PubMed] [Google Scholar]
  17. Onodera T., Taniguchi T., Yoshihara K., Sato M., Homma S. Pathogenicity of a reovirus type 2 in suckling mice: insulitis and lymphoid atrophy. Nihon Juigaku Zasshi. 1989 Oct;51(5):1071–1074. doi: 10.1292/jvms1939.51.1071. [DOI] [PubMed] [Google Scholar]
  18. Onodera T., Taniguchi T., Yoshihara K., Shimizu S., Sato M., Hayashi T. Reovirus type 2-induced diabetes in mice prevented by immunosuppression and thymic hormone. Diabetologia. 1990 Apr;33(4):192–196. doi: 10.1007/BF00404795. [DOI] [PubMed] [Google Scholar]
  19. Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203–1211. doi: 10.1016/0092-8674(89)90775-7. [DOI] [PubMed] [Google Scholar]
  20. Prieto J., Kaaya E. E., Juntti-Berggren L., Berggren P. O., Sandler S., Biberfeld P., Patarroyo M. Induction of intercellular adhesion molecule-1 (CD54) on isolated mouse pancreatic beta cells by inflammatory cytokines. Clin Immunol Immunopathol. 1992 Dec;65(3):247–253. doi: 10.1016/0090-1229(92)90154-g. [DOI] [PubMed] [Google Scholar]
  21. Rosenstein Y., Park J. K., Hahn W. C., Rosen F. S., Bierer B. E., Burakoff S. J. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature. 1991 Nov 21;354(6350):233–235. doi: 10.1038/354233a0. [DOI] [PubMed] [Google Scholar]
  22. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  23. Springer T. A., Dustin M. L., Kishimoto T. K., Marlin S. D. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Annu Rev Immunol. 1987;5:223–252. doi: 10.1146/annurev.iy.05.040187.001255. [DOI] [PubMed] [Google Scholar]
  24. Staunton D. E., Dustin M. L., Springer T. A. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature. 1989 May 4;339(6219):61–64. doi: 10.1038/339061a0. [DOI] [PubMed] [Google Scholar]
  25. Vives M., Soldevila G., Alcalde L., Lorenzo C., Somoza N., Pujol-Borrell R. Adhesion molecules in human islet beta-cells. De novo induction of ICAM-1 but not LFA-3. Diabetes. 1991 Nov;40(11):1382–1390. doi: 10.2337/diab.40.11.1382. [DOI] [PubMed] [Google Scholar]
  26. Yoon J. W., Austin M., Onodera T., Notkins A. L. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med. 1979 May 24;300(21):1173–1179. doi: 10.1056/NEJM197905243002102. [DOI] [PubMed] [Google Scholar]
  27. de Fougerolles A. R., Stacker S. A., Schwarting R., Springer T. A. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp Med. 1991 Jul 1;174(1):253–267. doi: 10.1084/jem.174.1.253. [DOI] [PMC free article] [PubMed] [Google Scholar]

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