Abstract
The effects of administering cyclosporin A (CsA), for periods of up to 84 days, on glucose homeostasis and renal function were studied in adult male Sprague-Dawley rats. Marked glucose intolerance was demonstrated at a variety of drug doses, accompanied in the longer term by hyperglycaemia. Early on and at high CsA dose, the abnormal islet cell function was accompanied by islet cell vacuolation; in the long-term dose groups, more chronic structural islet changes were present. Although abnormalities in renal function and structure were noted during this study, they were not directly related to the pancreatic changes observed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersson A., Borg H., Hallberg A., Hellerström C., Sandler S., Schnell A. Long-term effects of cyclosporin A on cultured mouse pancreatic islets. Diabetologia. 1984 Jul;27 (Suppl):66–69. doi: 10.1007/BF00275649. [DOI] [PubMed] [Google Scholar]
- Bertani T., Perico N., Abbate M., Battaglia C., Remuzzi G. Renal injury induced by long-term administration of cyclosporin A to rats. Am J Pathol. 1987 Jun;127(3):569–579. [PMC free article] [PubMed] [Google Scholar]
- Blair J. T., Thomson A. W., Whiting P. H., Davidson R. J., Simpson J. G. Toxicity of the immune suppressant cyclosporin A in the rat. J Pathol. 1982 Oct;138(2):163–178. doi: 10.1002/path.1711380206. [DOI] [PubMed] [Google Scholar]
- Chan P., Chapman J. R., Morris P. J. Glycosuria: an index of cyclosporine nephrotoxicity. Transplant Proc. 1987 Feb;19(1 Pt 2):1780–1780. [PubMed] [Google Scholar]
- Gunnarsson R., Klintmalm G., Lundgren G., Wilczek H., Ostman J., Groth C. G. Deterioration in glucose metabolism in pancreatic transplant recipients given cyclosporin. Lancet. 1983 Sep 3;2(8349):571–572. doi: 10.1016/s0140-6736(83)90598-6. [DOI] [PubMed] [Google Scholar]
- Hahn H. J., Laube F., Lucke S., Klöting I., Kohnert K. D., Warzock R. Toxic effects of cyclosporine on the endocrine pancreas of Wistar rats. Transplantation. 1986 Jan;41(1):44–47. doi: 10.1097/00007890-198601000-00008. [DOI] [PubMed] [Google Scholar]
- Kahan B. D., Van Buren C. T., Boileau M., Ried M., Payne W. D., Flechner S., Newburger J. Cyclosporin A tissue levels in a cadaveric renal allograft recipient. Transplantation. 1983 Jan;35(1):96–99. doi: 10.1097/00007890-198301000-00018. [DOI] [PubMed] [Google Scholar]
- Müller M. K., Bergmann K., Degenhardt H., Klöppel G., Löhr M., Coone H. J., Goebell H. Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine. Transplantation. 1988 Apr;45(4):698–700. doi: 10.1097/00007890-198804000-00006. [DOI] [PubMed] [Google Scholar]
- Ryffel B., Foxwell B. M., Gee A., Greiner B., Woerly G., Mihatsch M. J. Cyclosporine--relationship of side effects to mode of action. Transplantation. 1988 Aug;46(2 Suppl):90S–96S. doi: 10.1097/00007890-198808001-00017. [DOI] [PubMed] [Google Scholar]
- Stiller C. R., Dupré J., Gent M., Jenner M. R., Keown P. A., Laupacis A., Martell R., Rodger N. W., von Graffenried B., Wolfe B. M. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science. 1984 Mar 30;223(4643):1362–1367. doi: 10.1126/science.6367043. [DOI] [PubMed] [Google Scholar]
- Yale J. F., Roy R. D., Grose M., Seemayer T. A., Murphy G. F., Marliss E. B. Effects of cyclosporine on glucose tolerance in the rat. Diabetes. 1985 Dec;34(12):1309–1313. doi: 10.2337/diab.34.12.1309. [DOI] [PubMed] [Google Scholar]