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Journal of Experimental Pathology (Oxford, England) logoLink to Journal of Experimental Pathology (Oxford, England)
. 1990 Apr;71(2):197–208.

T-cell mediated cytolysis: evidence for target-cell suicide.

J Chayen 1, A A Pitsillides 1, L Bitensky 1, I H Muir 1, P M Taylor 1, B A Askonas 1
PMCID: PMC1998716  PMID: 2184871

Abstract

The mechanism by which cytotoxic T-lymphocytes (Tc) induce the death of specific target cells is still controversial. We have used quantitative cytochemical methods to distinguish the metabolic activities of the target cells from those of the Tc, even when they are attached to each other. Early events following Tc-P8(15) target cell interaction were first, increased glucose 6-phosphate dehydrogenase activity and second, labilization of the lysosomes within the target cell: these changes could be mimicked, in part, by polyamines and could be inhibited by inhibiting ornithine decarboxylase (ODC) activity. The crucial role of ODC in the chain of events that led to cytolysis in this particular experimental system was shown first, by measuring ODC activity directly and secondly, by the inhibition of cytolysis by the presence of a selective inhibitor of ODC activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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