Abstract
Four Ugandan patients (1 women, 3 men) with generalized Kaposi's sarcoma (KS) were seen in the Uganda Cancer Institute between October 1983 and December 1984. They presented with generalized lymphadenopathy, plaques/nodules on the body, general swelling of the head, oral and visceral involvement and respiratory distress. Initial responses to adriamycin as a single or a combination chemotherapy of actinomycin D, vincristine, adriamycin and imidazole carboxamide appeared to be favourable but no sustained response was obtained. Serological tests for human T-lymphotropic virus (HTLV-II) antibodies were positive in all 4 cases.
Full text
PDF



Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bayley A. C. Aggressive Kaposi's sarcoma in Zambia, 1983. Lancet. 1984 Jun 16;1(8390):1318–1320. doi: 10.1016/s0140-6736(84)91818-x. [DOI] [PubMed] [Google Scholar]
- Bayley A. C., Downing R. G., Cheingsong-Popov R., Tedder R. S., Dalgleish A. G., Weiss R. A. HTLV-III serology distinguishes atypical and endemic Kaposi's sarcoma in Africa. Lancet. 1985 Feb 16;1(8425):359–361. doi: 10.1016/s0140-6736(85)91383-2. [DOI] [PubMed] [Google Scholar]
- Cheingsong-Popov R., Weiss R. A., Dalgleish A., Tedder R. S., Shanson D. C., Jeffries D. J., Ferns R. B., Briggs E. M., Weller I. V., Mitton S. Prevalence of antibody to human T-lymphotropic virus type III in AIDS and AIDS-risk patients in Britain. Lancet. 1984 Sep 1;2(8401):477–480. doi: 10.1016/s0140-6736(84)92562-5. [DOI] [PubMed] [Google Scholar]
- Kyalwazi S. K. Kaposi's sarcoma: clinical features, experience in Uganda. Antibiot Chemother (1971) 1981;29:59–69. doi: 10.1159/000397440. [DOI] [PubMed] [Google Scholar]
- Levy J. A., Ziegler J. L. Acquired immunodeficiency syndrome is an opportunistic infection and Kaposi's sarcoma results from secondary immune stimulation. Lancet. 1983 Jul 9;2(8341):78–81. doi: 10.1016/s0140-6736(83)90062-4. [DOI] [PubMed] [Google Scholar]
- Novis B. H., King H., Bank S. Kaposi's sarcoma presenting with diarrhea and protein-losing enteropathy. Gastroenterology. 1974 Nov;67(5):996–1000. [PubMed] [Google Scholar]
- Olweny C. L., Kaddumukasa A., Atine I., Owor R., Magrath I., Ziegler J. L. Childhood Kaposi's sarcoma: clinical features and therapy. Br J Cancer. 1976 May;33(5):555–560. doi: 10.1038/bjc.1976.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olweny C. L. Management of Kaposi's sarcoma. Chemotherapy II. Antibiot Chemother (1971) 1981;29:88–99. [PubMed] [Google Scholar]
- Olweny C. L., Toya T., Mbidde E. K., Lwanga S. K. Treatment of Kaposi's sarcoma by combination of actinomycin-D, vincristine and imidazole carboxamide (nsc-45388): results of a randomized clinical trial. Int J Cancer. 1974 Nov 15;14(5):649–656. doi: 10.1002/ijc.2910140512. [DOI] [PubMed] [Google Scholar]
- Saxinger W. C., Levine P. H., Dean A. G., de Thé G., Lange-Wantzin G., Moghissi J., Laurent F., Hoh M., Sarngadharan M. G., Gallo R. C. Evidence for exposure to HTLV-III in Uganda before 1973. Science. 1985 Mar 1;227(4690):1036–1038. doi: 10.1126/science.2983417. [DOI] [PubMed] [Google Scholar]
- Serwadda D., Mugerwa R. D., Sewankambo N. K., Lwegaba A., Carswell J. W., Kirya G. B., Bayley A. C., Downing R. G., Tedder R. S., Clayden S. A. Slim disease: a new disease in Uganda and its association with HTLV-III infection. Lancet. 1985 Oct 19;2(8460):849–852. doi: 10.1016/S0140-6736(85)90122-9. [DOI] [PubMed] [Google Scholar]
- Taylor J. F., Templeton A. C., Vogel C. L., Ziegler J. L., Kyalwazi S. K. Kaposi's sarcoma in Uganda: a clinico-pathological study. Int J Cancer. 1971 Jul 15;8(1):122–135. doi: 10.1002/ijc.2910080116. [DOI] [PubMed] [Google Scholar]
- Templeton A. C. Studies in Kaposi's sarcoma. Postmortem findings and disease patterns in women. Cancer. 1972 Sep;30(3):854–867. doi: 10.1002/1097-0142(197209)30:3<854::aid-cncr2820300337>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Vogel C. L., Primack A., Owor R., Kyalwazi S. K. Effective treatment of Kaposi's sarcoma with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388). Cancer Chemother Rep. 1973 Feb;57(1):65–71. [PubMed] [Google Scholar]


