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. 1986 Apr;53(4):477–481. doi: 10.1038/bjc.1986.75

DNA aneuploidy in colorectal adenomas.

P Quirke, J B Fozard, M F Dixon, J E Dyson, G R Giles, C C Bird
PMCID: PMC2001435  PMID: 3707842

Abstract

The frequency of DNA aneuploidy was investigated by flow cytometry in 156 colorectal adenomas including 56 associated with 36 synchronous adenocarcinomas. Nine of 156 adenomas (6%) were DNA aneuploid. DNA aneuploidy correlated with increasing size (P less than 0.005) and histopathological type P less than 0.05) but not with dysplasia. Adenomas in associated with a synchronous adenocarcinoma did not have an increased incidence of DNA aneuploidy. Adenocarcinomas found in association with adenomas tend to have a lower incidence of DNA aneuploidy then the generality of colorectal cancers.

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Selected References

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