Abstract
4-Hydroxyanisole (4-OHA) was administered to C57Bl/10J mice in which B16 melanoma or Lewis lung carcinoma had been implanted s.c. or i.m. The drug had the largest antitumour effect against B16 melanoma growing s.c. and a smaller antitumour effect against B16 melanoma or Lewis lung carcinoma growing i.m. In the treatment regimens where drug was administered only after tumour implantation, a significant reduction in number of spontaneous metastases and their incidence was observed. Again, the largest antimetastatic effect was observed for s.c. B16 melanoma with smaller effects observed for i.m. B16 melanoma or Lewis lung carcinoma. Experiments in which 4-OHA treatment was initiated after amputation of the primary tumour implanted in the tail confirmed that 4-OHA did have antitumour activity against disseminated tumour cells. The drug regimens studied to date produced significant delays in the appearance of spontaneous metastases in the lungs and significant increases in the life spans of the treated animals.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Breathnach A., Robins E., Ethridge L., Bhasin Y., Gallagher S., Passi S., Nazzaro-Porro M. Ultrastructural and biochemical observations on the effect of 4-hydroxyanisole plus tyrosinase on normal human melanocytes and keratocytes in tissue culture. Br J Cancer. 1983 Jun;47(6):813–822. doi: 10.1038/bjc.1983.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dewey D. L., Butcher F. W., Galpine A. R. Hydroxyanisole-induced regression of the Harding-Passey melanoma in mice. J Pathol. 1977 Jul;122(3):117–127. doi: 10.1002/path.1711220302. [DOI] [PubMed] [Google Scholar]
- Frenk E., Ott F. Evaluation of the toxicity of the monoethyl ether of hydroquinone for mammalian melanocytes and melanoma cells. J Invest Dermatol. 1971 Apr;56(4):287–293. doi: 10.1111/1523-1747.ep12261029. [DOI] [PubMed] [Google Scholar]
- Kanclerz A., Zbytniewski Z., Boeryd B. Influence of some synthetic antioxidants on the growth and metastases formation of Lewis lung carcinoma and amelanotic B16 melanoma in C57BL mice. Arch Geschwulstforsch. 1981;51(5):379–385. [PubMed] [Google Scholar]
- Kanclerz A., Zbytniewski Z. Vliv antioxidacních látek -terc.-butyl-4-hydroxyanisolu a 4-methyl-2, 6-di-terc. butylfenolu na B-16 melanotický melanom. Cesk Dermatol. 1981 Apr;56(2):85–88. [PubMed] [Google Scholar]
- Morgan B. D., O'Neill T., Dewey D. L., Galpine A. R., Riley P. A. Treatment of malignant melanoma by intravascular 4-hydroxyanisole. Clin Oncol. 1981 Sep;7(3):227–234. [PubMed] [Google Scholar]
- Paslin D. A. The effects of depigmenting agents on the growth of a transplantable hamster melanoma. Acta Derm Venereol. 1973;53(2):119–122. [PubMed] [Google Scholar]
- Riley P. A., Sawyer B., Wolf M. A. The melanocytotoxic action of 4-hydroxyanisole. J Invest Dermatol. 1975 Feb;64(2):86–89. doi: 10.1111/1523-1747.ep12510304. [DOI] [PubMed] [Google Scholar]