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. 1986 Oct;54(4):657–660. doi: 10.1038/bjc.1986.223

Role of aminoglutethimide in male breast cancer.

A L Harris, M Dowsett, R Stuart-Harris, I E Smith
PMCID: PMC2001494  PMID: 3778807

Abstract

Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomized patient and should only be used after orchidectomy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Epstein B. J., Raheja M. C., Frow E., Morse W. I. Estrogen synthesis in normal and hypogonadal men. Quantitative studies on the precursor role of testosterone. Can J Biochem. 1966 Jun;44(6):971–977. doi: 10.1139/o66-113. [DOI] [PubMed] [Google Scholar]
  2. Everson R. B., Lippman M. E., Thompson E. B., McGuire W. L., Wittliff J. L., De Sombre E. R., Jensen E. V., Singhakowinta A., Brooks S. C., Jr, Neifeld J. P. Clinical correlations of steroid receptors and male breast cancer. Cancer Res. 1980 Apr;40(4):991–997. [PubMed] [Google Scholar]
  3. Harris A. L., Dowsett M., Jeffcoate S. L., McKinna J. A., Morgan M., Smith I. E. Endocrine and therapeutic effects of aminoglutethimide in premenopausal patients with breast cancer. J Clin Endocrinol Metab. 1982 Oct;55(4):718–722. doi: 10.1210/jcem-55-4-718. [DOI] [PubMed] [Google Scholar]
  4. Harris A. L., Dowsett M., Jeffcoate S. L., Smith I. E. Aminoglutethimide dose and hormone suppression in advanced breast cancer. Eur J Cancer Clin Oncol. 1983 Apr;19(4):493–498. doi: 10.1016/0277-5379(83)90112-8. [DOI] [PubMed] [Google Scholar]
  5. Harris A. L., Dowsett M., Smith I. E., Jeffcoate S. L. Endocrine effects of low dose aminoglutethimide alone in advanced postmenopausal breast cancer. Br J Cancer. 1983 May;47(5):621–627. doi: 10.1038/bjc.1983.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harris A. L., Powles T. J., Smith I. E. Aminoglutethimide in the treatment of advanced postmenopausal breast cancer. Cancer Res. 1982 Aug;42(8 Suppl):3405s–3408s. [PubMed] [Google Scholar]
  7. Kantarjian H., Yap H. Y., Hortobagyi G., Buzdar A., Blumenschein G. Hormonal therapy for metastatic male breast cancer. Arch Intern Med. 1983 Feb;143(2):237–240. [PubMed] [Google Scholar]
  8. Kraybill W. G., Kaufman R., Kinne D. Treatment of advanced male breast cancer. Cancer. 1981 May 1;47(9):2185–2189. doi: 10.1002/1097-0142(19810501)47:9<2185::aid-cncr2820470913>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  9. Meyskens F. L., Jr, Tormey D. C., Neifeld J. P. Male breast cancer: a review. Cancer Treat Rev. 1976 Jun;3(2):83–93. doi: 10.1016/s0305-7372(76)80006-0. [DOI] [PubMed] [Google Scholar]
  10. Nirmul D., Pegoraro R. J., Jialal I., Naidoo C., Joubert S. M. The sex hormone profile of male patients with breast cancer. Br J Cancer. 1983 Sep;48(3):423–427. doi: 10.1038/bjc.1983.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Patel J. K., Nemoto T., Dao T. L. Metastatic breast cancer in males. Assessment of endocrine therapy. Cancer. 1984 Mar 15;53(6):1344–1346. doi: 10.1002/1097-0142(19840315)53:6<1344::aid-cncr2820530621>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  12. Patterson J. S., Battersby L. A., Bach B. K. Use of tamoxifen in advanced male breast cancer. Cancer Treat Rep. 1980 Jun-Jul;64(6-7):801–804. [PubMed] [Google Scholar]
  13. Ribeiro G. G. Tamoxifen in the treatment of male breast carcinoma. Clin Radiol. 1983 Nov;34(6):625–628. doi: 10.1016/s0009-9260(83)80408-5. [DOI] [PubMed] [Google Scholar]
  14. Ribeiro G. G. The results of diethylstilboestrol therapy for recurrent and metastatic carcinoma of the male breast. Br J Cancer. 1976 Apr;33(4):465–467. doi: 10.1038/bjc.1976.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ribeiro G. Male breast carcinoma--a review of 301 cases from the Christie Hospital & Holt Radium Institute, Manchester. Br J Cancer. 1985 Jan;51(1):115–119. doi: 10.1038/bjc.1985.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Santen R. J., Cohn N., Misbin R., Samojlik E., Foltz E. Acute effects of aminoglutethimide on testicular steroidogenesis in normal men. J Clin Endocrinol Metab. 1979 Oct;49(4):631–634. doi: 10.1210/jcem-49-4-631. [DOI] [PubMed] [Google Scholar]
  17. Wu F. C., Swanston I. A., Hargreave T. B., Baird D. T. Human testis does not secrete oestrone sulphate. J Endocrinol. 1982 Feb;92(2):185–194. doi: 10.1677/joe.0.0920185. [DOI] [PubMed] [Google Scholar]

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