Abstract
Trends in prevalence of cytological evidence of cervical intraepithelial neoplasia (CIN) and cervical infection with human papilloma virus (HPV), as indicated by HPV infection and dyskeratosis, were studied in 2,992 new attenders at a sexually transmitted diseases (STD) clinic between 1978 and 1982. Crude prevalence of CIN increased from 1.3% to 4.3% (P less than 0.001) and crude prevalence of HPV infection increased from 2.8% to 9.3% (P less than 0.001). Age adjustment had little effect on these trends. Review, in 1984-85, of samples of smears taken in 1978 and 1982 showed that recognition of koilocytosis by the laboratory had increased substantially over time while a tendency had developed to downgrade nuclear changes in the presence of koilocytosis. Correction of the 1978 and 1982 smear results to the 1984-85 classifications suggested that prevalence of koilocytosis had increased little (from 13.4% to 16.1%, P = 0.20) while there had been a substantial real increase in CIN (0.8% to 2.4%, P less than 0.001). To try to explain the trend in CIN, other characteristics of a sample of attenders at the STD clinic were studied. There were no appreciable trends in prevalence of past STD, number of sexual partners in the last 3 months, method of contraception, genital warts and culture of N. gonorrhoea, T. vaginalis, C. albicans and Chlamydia sp. from the vagina. There was an increase in the proportions in socioeconomic group I, as classified by postcode of residence (17.0% to 26.9%, P = 0.04), referred as contacts rather than with symptoms (24.0% to 41.6%, P less than 0.001), with a clinical diagnosis of genital herpes (5.0% to 8.6%, P = 0.08) and with herpes virus cultured from the cervix (2.1% to 6.3%, P = 0.03). The trend in prevalence of herpes virus infection was not explained by the other trends. It may explain the trend in prevalence of CIN.
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- Armstrong B., Holman D. Increasing mortality from cancer of the cervix in young Australian women. Med J Aust. 1981 May 2;1(9):460–462. doi: 10.5694/j.1326-5377.1981.tb135734.x. [DOI] [PubMed] [Google Scholar]
- Baird P. J. Serological evidence for the association of papillomavirus and cervical neoplasia. Lancet. 1983 Jul 2;2(8340):17–18. doi: 10.1016/s0140-6736(83)90006-5. [DOI] [PubMed] [Google Scholar]
- Gray N. J., Hill D. J. Patterns of tobacco smoking in Australia. 2. Med J Aust. 1977 Sep 3;2(10):327–328. doi: 10.5694/j.1326-5377.1977.tb99167.x. [DOI] [PubMed] [Google Scholar]
- Gray N. J., Hill D. J. Patterns of tobacco smoking in Australia. Med J Aust. 1975 Nov 29;2(22):819–822. [PubMed] [Google Scholar]
- Harris R. W., Brinton L. A., Cowdell R. H., Skegg D. C., Smith P. G., Vessey M. P., Doll R. Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri. Br J Cancer. 1980 Sep;42(3):359–369. doi: 10.1038/bjc.1980.246. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill D. J., Gray N. J. Patterns of tobacco smoking in Australia. Med J Aust. 1982 Jan 9;1(1):23–25. [PubMed] [Google Scholar]
- Hill D., Gray N. Australian patterns of tobacco smoking and related health beliefs in 1983. Community Health Stud. 1984;8(3):307–316. doi: 10.1111/j.1753-6405.1984.tb00459.x. [DOI] [PubMed] [Google Scholar]
- Horn P. L., Lowell D. M., LiVolsi V. A., Boyle C. A. Reproducibility of the cytologic diagnosis of human papillomavirus infection. Acta Cytol. 1985 Sep-Oct;29(5):692–694. [PubMed] [Google Scholar]
- Winkelstein W., Jr, Shillitoe E. J., Brand R., Johnson K. K. Further comments on cancer of the uterine cervix, smoking, and herpesvirus infection. Am J Epidemiol. 1984 Jan;119(1):1–8. doi: 10.1093/oxfordjournals.aje.a113711. [DOI] [PubMed] [Google Scholar]