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. 1986 Sep;54(3):409–414. doi: 10.1038/bjc.1986.191

Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue.

T Wiggers, J W Arends, C Verstijnen, P M Moerkerk, F T Bosman
PMCID: PMC2001613  PMID: 3756077

Abstract

In order to determine the clinical value of CEA detection in large bowel cancer tissue the patterns rather than the intensity of immunoreactivity of CEA reactive antibodies were analyzed in 312 large bowel cancer patients especially in relation to patient survival. CEA immunoreactivity appeared to be distinguishable into a predominantly apical/cytoplasmic and a predominantly membranous pattern. Twenty-four (7.7%) tumours were found to be CEA negative or only focally positive. Two hundred and eighty-three (90.7%) of the carcinomas showed a predominantly apical/cytoplasmic immunoreactivity pattern, whereas 5 (1.6%) of the tumours revealed mostly membranous CEA immunoreactivity. CEA negative or focally positive carcinomas and CEA positive tumours with membranous immunoreactivity were significantly more often observed in the group of poorly differentiated carcinomas (P greater than 0.001), but showed no significant correlation with stage of tumour extension (P = 0.11). Also, these carcinomas demonstrated a more aggressive course in patients compared to CEA positive tumours with an apical/cytoplasmic CEA expression pattern. We, therefore, conclude that determination of the pattern of CEA immunoreactivity in large bowel cancer tissue may enable the detection of subgroups of patients with a poor prognosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahnen D. J., Nakane P. K., Brown W. R. Ultrastructural localization of carcinoembryonic antigen in normal intestine and colon cancer: abnormal distribution of CEA on the surfaces of colon cancer cells. Cancer. 1982 May 15;49(10):2077–2090. doi: 10.1002/1097-0142(19820515)49:10<2077::aid-cncr2820491020>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  2. Arends J. W., Verstynen C., Bosman F. T., Hilgers J., Steplewski Z. Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissues: an immunoperoxidase study. Hybridoma. 1983;2(2):219–229. doi: 10.1089/hyb.1983.2.219. [DOI] [PubMed] [Google Scholar]
  3. Blenkinsopp W. K., Stewart-Brown S., Blesovsky L., Kearney G., Fielding L. P. Histopathology reporting in large bowel cancer. J Clin Pathol. 1981 May;34(5):509–513. doi: 10.1136/jcp.34.5.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Denk H., Tappeiner G., Eckerstorfer R., Holzner J. H. Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation. Int J Cancer. 1972 Sep 15;10(2):262–272. doi: 10.1002/ijc.2910100206. [DOI] [PubMed] [Google Scholar]
  5. Goldenberg D. M., Sharkey R. M., Primus F. J. Carcinoembryonic antigen in histopathology: immunoperoxidase staining of conventional tissue sections. J Natl Cancer Inst. 1976 Jul;57(1):11–22. doi: 10.1093/jnci/57.1.11. [DOI] [PubMed] [Google Scholar]
  6. Goslin R., O'Brien M. J., Steele G., Mayer R., Wilson R., Corson J. M., Zamcheck N. Correlation of Plasma CEA and CEA tissue staining in poorly differentiated colorectal cancer. Am J Med. 1981 Aug;71(2):246–253. doi: 10.1016/0002-9343(81)90125-x. [DOI] [PubMed] [Google Scholar]
  7. Hamada Y., Yamamura M., Hioki K., Yamamoto M., Nagura H., Watanabe K. Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels. Cancer. 1985 Jan 1;55(1):136–141. doi: 10.1002/1097-0142(19850101)55:1<136::aid-cncr2820550121>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  8. Huitric E., Laumonier R., Burtin P., Von Kleist S., Chavanel G. An optical and ultrastructural study of the localization of carcinoembryonic antigen (CEA) in normal and cancerous human rectocolonic mucosa. Lab Invest. 1976 Jan;34(1):97–107. [PubMed] [Google Scholar]
  9. Lewis J. C., Keep P. A. Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts. Br J Cancer. 1981 Sep;44(3):381–387. doi: 10.1038/bjc.1981.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. O'Brien M. J., Zamcheck N., Burke B., Kirkham S. E., Saravis C. A., Gottlieb L. S. Immunocytochemical localization of carcinoembryonic antigen in benign and malignant colorectal tissues. Assessment of diagnostic value. Am J Clin Pathol. 1981 Mar;75(3):283–290. doi: 10.1093/ajcp/75.3.283. [DOI] [PubMed] [Google Scholar]
  11. QUALHEIM R. E., GALL E. A. Is histologic grading of colon carcinoma a valid procedure? AMA Arch Pathol. 1953 Nov;56(5):466–472. [PubMed] [Google Scholar]
  12. Rognum T. O., Thorud E., Elgjo K., Brandtzaeg P., Orjasaeter H., Nygaard K. Large-bowel carcinomas with different ploidy, related to secretory component, IgA, and CEA in epithelium and plasma. Br J Cancer. 1982 Jun;45(6):921–934. doi: 10.1038/bjc.1982.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Turnbull R. B., Jr, Kyle K., Watson F. R., Spratt J. Cancer of the colon: the influence of the no-touch isolation technic on survival rates. Ann Surg. 1967 Sep;166(3):420–427. doi: 10.1097/00000658-196709000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Verstijnen C. P., Arends J. W., Moerkerk P. T., Warnaar S., Hilgers J., Bosman F. T. CEA-specificity of CEA-reactive monoclonal antibodies. Immunochemical and immunocytochemical studies. Anticancer Res. 1986 Jan-Feb;6(1):97–104. [PubMed] [Google Scholar]

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