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. 1987 Apr;55(4):463–466. doi: 10.1038/bjc.1987.91

Second malignancies in children treated for non-Hodgkin's lymphoma and T-cell leukaemia with the UKCCSG regimens.

L Ingram, M G Mott, J R Mann, F Raafat, P J Darbyshire, P H Morris Jones
PMCID: PMC2001694  PMID: 3495284

Abstract

Eight children treated between 1977 and 1983 with the UK Children's Cancer Study Group's non-Hodgkin lymphoma (NHL) and T-cell protocols have developed second malignancies within 7 years of commencing treatment. Five developed acute non-lymphoblastic leukaemia and a sixth died from infection while pancytopenic with a pre-leukaemic marrow. The other malignancies were cerebral astrocytoma and an undifferentiated low grade sarcoma. These eight children were included among 261 children studied in the first UKCCSG NHL and T-cell trials giving an actuarial incidence of 7.8% second malignancy at 7 years. Six had received adjuvant radiotherapy which may have contributed to the high incidence of second malignancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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