Abstract
The zona glomerulosa of the adrenal glands was studied histologically, ultrastructurally and morphometrically in portacaval shunt (PCS)-bearing rats 4 weeks after surgery. Compared with controls, the zona glomerulosa of rats with PCS showed an increase in thickness and a reduction in the number of lipid droplets in the cells of its inner portion, adjacent to the intermediate zone. Moreover, electron microscopy and morphometry of the cells of the inner portion revealed that qualitative and quantitative changes occur, consisting in a decrease in lipid droplets, an increase in the amounts of smooth endoplasmic reticulum and mitochondria, enlargement of the Golgi apparatus, and the appearance of numerous dense bodies at the vascular cell poles. All the above findings indicate that PCS induces an enhanced activity of the fully differentiated cells of the zona glomerulosa, which may be considered as an adaptive response--mediated by an activation of the renin-angiotensin system--to the lowering of the systemic pressure taking place in this experimental condition.
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- Hashida Y., Yunis E. J. Ultrastructure of the adrenal zona glomerulosa in children with renovascular hypertension. Hum Pathol. 1972 Sep;3(3):301–315. doi: 10.1016/s0046-8177(72)80032-7. [DOI] [PubMed] [Google Scholar]
- LEE S. H., FISHER B. Portacaval shunt in the rat. Surgery. 1961 Oct;50:668–672. [PubMed] [Google Scholar]
- LUFT J. H. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961 Feb;9:409–414. doi: 10.1083/jcb.9.2.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lauterburg B., Bircher J. Defective renal handling of water in the rat with a portacaval shunt. Eur J Clin Invest. 1976 Nov 30;6(6):439–444. doi: 10.1111/j.1365-2362.1976.tb00540.x. [DOI] [PubMed] [Google Scholar]
- Moses H. L., Davis W. W., Rosenthal A. S., Garren L. D. Adrenal cholesterol: localization by electron-microscope autoradiography. Science. 1969 Mar 14;163(3872):1203–1205. doi: 10.1126/science.163.3872.1203. [DOI] [PubMed] [Google Scholar]
- Nussdorfer G. G. Cytophysiology of the adrenal cortex. Int Rev Cytol. 1986;98:1–405. [PubMed] [Google Scholar]
- Rebuffat P., Belloni A. S., Mazzocchi G., Vassanelli P., Nussdorfer G. G. A stereological study of the trophic effects of the renin-angiotensin system on the rat adrenal zona glomerulosa. J Anat. 1979 Oct;129(Pt 3):561–570. [PMC free article] [PubMed] [Google Scholar]
- Sharawy M., Dirksen T., Chaffin J. Increase in free cholesterol content of the adrenal cortex after stress: radioautographic and biochemical study. Am J Anat. 1979 Dec;156(4):567–575. doi: 10.1002/aja.1001560409. [DOI] [PubMed] [Google Scholar]
- TAKAHASHI H., TIBA M., YAMAZAKI T., NOGUCHI F. On the site of action of gamma-aminobutyric acid on blood pressure. Jpn J Physiol. 1958 Dec 20;8(4):378–390. doi: 10.2170/jjphysiol.8.378. [DOI] [PubMed] [Google Scholar]
- Tamaoki B. Steroidogenesis and cell structure. Biochemical pursuit of sites of steroid biosynthesis. J Steroid Biochem. 1973 Jan;4(1):89–118. doi: 10.1016/0022-4731(73)90084-8. [DOI] [PubMed] [Google Scholar]
- Vander A. J. Control of renin release. Physiol Rev. 1967 Jul;47(3):359–382. doi: 10.1152/physrev.1967.47.3.359. [DOI] [PubMed] [Google Scholar]