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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1992 Apr;73(2):147–155.

Heparin enhances angiogenesis by a systemic mode of action.

K Norrby 1, J Sörbo 1
PMCID: PMC2001995  PMID: 1373951

Abstract

A systemically-administered standard sodium heparin, but not an oligosaccharide fraction derived from the heparin, significantly potentiated angiogenesis induced by saline in normal rats, as assessed by the quantitative mesenteric window angiogenesis assay. This is the first unambiguous evidence that any single specific mast-cell product can potentiate angiogenesis in normally vascularized mammalian tissue. Whether systemic treatment with a heparin-like substance may be useful for stimulating neoangiogenic formation of collaterals in situations of relative microvascular insufficiency, such as coronary collaterals in patients suffering from ischaemic heart disease, is briefly discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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