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. 1987 Feb;55(2):197–201. doi: 10.1038/bjc.1987.37

Placental-type alkaline phosphatase in cervical neoplasia.

P J McLaughlin, P H Warne, G E Hutchinson, P M Johnson, D F Tucker
PMCID: PMC2002092  PMID: 3028462

Abstract

Monoclonal antibodies reactive with placental-type alkaline phosphatase have formed the basis of methods for detection of this oncodevelopmental antigen in patients with pre-invasive and invasive cervical neoplasia, with or without evidence of papilloma virus infection. Disease-related elevations of placental-type alkaline phosphatase were not observed in patients' sera. Solubilised cervical smears or biopsy material, and cervical mucus swabs, often contained substantial amounts of this isoenzyme; however, there was no significant difference between any of the patient and control groups. Thus, serological and smear test assays for placental-type alkaline phosphatase were not useful in differential diagnosis of cervical lesions. However, its presence in most biopsy specimens, often at high levels, indicated possible application for in vivo radioimmunoimaging studies of invasive or metastatic cervical cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crawford L. Papilloma viruses and cervical tumours. Nature. 1984 Jul 5;310(5972):16–16. doi: 10.1038/310016a0. [DOI] [PubMed] [Google Scholar]
  2. Critchley M., Brownless S., Patten M., McLaughlin P. J., Tromans P. M., McDicken I. W., Johnson P. M. Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase. Clin Radiol. 1986 Mar;37(2):107–112. doi: 10.1016/s0009-9260(86)80373-7. [DOI] [PubMed] [Google Scholar]
  3. Davies J. O., Howe K., Stirrat G. M., Sunderland C. A. Placental alkaline phosphatase in benign and malignant endometrium. Histochem J. 1985 May;17(5):605–612. doi: 10.1007/BF01003200. [DOI] [PubMed] [Google Scholar]
  4. Epenetos A. A. Antibody guided lymphangiography in the staging of cervical cancer. Br J Cancer. 1985 Jun;51(6):805–808. doi: 10.1038/bjc.1985.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Epenetos A. A., Munro A. J., Tucker D. F., Gregory W., Duncan W., MacDougall R. H., Faux M., Travers P., Bodmer W. F. Monoclonal antibody assay of serum placental alkaline phosphatase in the monitoring of testicular tumours. Br J Cancer. 1985 May;51(5):641–644. doi: 10.1038/bjc.1985.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ey P. L., Prowse S. J., Jenkin C. R. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry. 1978 Jul;15(7):429–436. doi: 10.1016/0161-5890(78)90070-6. [DOI] [PubMed] [Google Scholar]
  7. Goldstein D. J., Blasco L., Harris H. Placental alkaline phosphatase in nonmalignant human cervix. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4226–4228. doi: 10.1073/pnas.77.7.4226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greenberg E. R., Vessey M., McPherson K., Yeates D. Cigarette smoking and cancer of the uterine cervix. Br J Cancer. 1985 Jan;51(1):139–141. doi: 10.1038/bjc.1985.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Horwich A., Tucker D. F., Peckham M. J. Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay. Br J Cancer. 1985 May;51(5):625–629. doi: 10.1038/bjc.1985.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Maslow W. C., Muensch H. A., Azama F., Schneider A. S. Sensitive fluorometry of heat-stable alkaline phosphatase (Regan enzyme) activity in serum from smokers and nonsmokers. Clin Chem. 1983 Feb;29(2):260–263. [PubMed] [Google Scholar]
  11. McCance D. J., Campion M. J., Clarkson P. K., Chesters P. M., Jenkins D., Singer A. Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix. Br J Obstet Gynaecol. 1985 Nov;92(11):1101–1105. doi: 10.1111/j.1471-0528.1985.tb03019.x. [DOI] [PubMed] [Google Scholar]
  12. McDicken I. W., McLaughlin P. J., Tromans P. M., Luesley D. M., Johnson P. M. Detection of placental-type alkaline phosphatase in ovarian cancer. Br J Cancer. 1985 Jul;52(1):59–64. doi: 10.1038/bjc.1985.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McDicken I. W., Stamp G. H., McLaughlin P. J., Johnson P. M. Expression of human placental-type alkaline phosphatase in primary breast cancer. Int J Cancer. 1983 Aug 15;32(2):205–209. doi: 10.1002/ijc.2910320211. [DOI] [PubMed] [Google Scholar]
  14. McLaughlin P. J., Gee H., Johnson P. M. Placental-type alkaline phosphatase in pregnancy and malignancy plasma: specific estimation using a monoclonal antibody in a solid phase enzyme immunoassay. Clin Chim Acta. 1983 May 30;130(2):199–209. doi: 10.1016/0009-8981(83)90117-1. [DOI] [PubMed] [Google Scholar]
  15. McLaughlin P. J., Travers P. J., McDicken I. W., Johnson P. M. Demonstration of placental and placental-like alkaline phosphatase in non-malignant human tissue extracts using monoclonal antibodies in an enzyme immunoassay. Clin Chim Acta. 1984 Mar 13;137(3):341–348. doi: 10.1016/0009-8981(84)90122-0. [DOI] [PubMed] [Google Scholar]
  16. McLaughlin P. J., Twist A. M., Evans C. C., Johnson P. M. Serum placental type alkaline phosphatase in cigarette smokers. J Clin Pathol. 1984 Jul;37(7):826–828. doi: 10.1136/jcp.37.7.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Syrjänen K., Väyrynen M., Saarikoski S., Mäntyjärvi R., Parkkinen S., Hippeläinen M., Castren O. Natural history of cervical human papillomavirus (HPV) infections based on prospective follow-up. Br J Obstet Gynaecol. 1985 Nov;92(11):1086–1092. [PubMed] [Google Scholar]
  18. Tonik S. E., Ortmeyer A. E., Shindelman J. E., Sussman H. H. Elevation of serum placental alkaline phosphatase levels in cigarette smokers. Int J Cancer. 1983 Jan 15;31(1):51–53. doi: 10.1002/ijc.2910310109. [DOI] [PubMed] [Google Scholar]
  19. Travers P., Bodmer W. Preparation and characterization of monoclonal antibodies against placental alkaline phosphatase and other human trophoblast-associated determinants. Int J Cancer. 1984 May 15;33(5):633–641. doi: 10.1002/ijc.2910330514. [DOI] [PubMed] [Google Scholar]
  20. Tucker D. F., Oliver R. T., Travers P., Bodmer W. F. Serum marker potential of placental alkaline phosphatase-like activity in testicular germ cell tumours evaluated by H17E2 monoclonal antibody assay. Br J Cancer. 1985 May;51(5):631–639. doi: 10.1038/bjc.1985.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Williams G. H., McLaughlin P. J., Johnson P. M. Tissue origin of serum placental-like alkaline phosphatase in cigarette smokers. Clin Chim Acta. 1986 Mar 28;155(3):329–333. doi: 10.1016/0009-8981(86)90252-4. [DOI] [PubMed] [Google Scholar]
  22. Winkelstein W., Jr, Shillitoe E. J., Brand R., Johnson K. K. Further comments on cancer of the uterine cervix, smoking, and herpesvirus infection. Am J Epidemiol. 1984 Jan;119(1):1–8. doi: 10.1093/oxfordjournals.aje.a113711. [DOI] [PubMed] [Google Scholar]

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