Skip to main content
NCBI home page
International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1993 Jun;74(3):267–274.

Changes in collagen fibril morphology in experimental aneurysms and arteriovenous fistulae in sheep.

B J Martin 1, B S Leppien 1, W E Stehbens 1
PMCID: PMC2002155  PMID: 8334076

Abstract

To investigate the effect of haemodynamic stress on collagen fibril morphology, the ultrastructure of intimal and adventitial collagen in the walls of experimental saccular aneurysms and in the veins of arteriovenous fistulae in sheep was compared with that of adventitial collagen from control veins. Ultrastructurally the collagen fibril is usually described as having a regular round profile in cross-section and a diameter dependent on collagen function and location in the blood vessel wall. The collagen fibrils in the intimal proliferation from both experimental models showed increased variation in shape and size when compared with adventitial collagen. These abnormally shaped collagen fibrils resemble those seen in inherited connective tissue disorders and in blood vessels from aged animals, suggesting that the collagen changes can be acquired and can be produced experimentally in blood vessels subjected to augmented haemodynamic stress.

Full text

PDF
267

Images in this article

270Figure 1
on p.270
273Figure 4
on p.273

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker P. B., Bansal G., Boudoulas H., Kolibash A. J., Kilman J., Wooley C. F. Floppy mitral valve chordae tendineae: histopathologic alterations. Hum Pathol. 1988 May;19(5):507–512. doi: 10.1016/s0046-8177(88)80195-3. [DOI] [PubMed] [Google Scholar]
  2. Breiteneder-Geleff S., Mallinger R., Böck P. Quantitation of collagen fibril cross-section profiles in aging human veins. Hum Pathol. 1990 Oct;21(10):1031–1035. doi: 10.1016/0046-8177(90)90252-z. [DOI] [PubMed] [Google Scholar]
  3. Byers P. H., Holbrook K. A., McGillivray B., MacLeod P. M., Lowry R. B. Clinical and ultrastructural heterogeneity of type IV Ehlers-Danlos syndrome. Hum Genet. 1979 Mar 12;47(2):141–150. doi: 10.1007/BF00273196. [DOI] [PubMed] [Google Scholar]
  4. Crowther M. A., Lach B., Dunmore P. J., Roach M. R. Vascular collagen fibril morphology in type IV Ehlers-Danlos syndrome. Connect Tissue Res. 1991;25(3-4):209–217. doi: 10.3109/03008209109029157. [DOI] [PubMed] [Google Scholar]
  5. Fjolstad M., Helle O. A hereditary dysplasia of collagen tissues in sheep. J Pathol. 1974 Mar;112(3):183–188. doi: 10.1002/path.1711120309. [DOI] [PubMed] [Google Scholar]
  6. Frank C., Bray D., Rademaker A., Chrusch C., Sabiston P., Bodie D., Rangayyan R. Electron microscopic quantification of collagen fibril diameters in the rabbit medial collateral ligament: a baseline for comparison. Connect Tissue Res. 1989;19(1):11–25. doi: 10.3109/03008208909016811. [DOI] [PubMed] [Google Scholar]
  7. Peracchia C., Vassallo C. Alterations in collagen in the arteries of thromboangiitic patients. Angiology. 1966 Jul;17(7):451–459. doi: 10.1177/000331976601700702. [DOI] [PubMed] [Google Scholar]
  8. Scheck M., Siegel R. C., Parker J., Chang Y. H., Fu J. C. Aortic aneurysm in Marfan's syndrome: changes in the ultrastructure and composition of collagen. J Anat. 1979 Oct;129(Pt 3):645–657. [PMC free article] [PubMed] [Google Scholar]
  9. Staubesand J., Fischer N. The ultrastructural characteristics of abnormal collagen fibrils in various organs. Connect Tissue Res. 1980;7(4):213–217. doi: 10.3109/03008208009152356. [DOI] [PubMed] [Google Scholar]
  10. Stehbens W. E. Cerebral atherosclerosis. Intimal proliferation and atherosclerosis in the cerebral arteries. Arch Pathol. 1975 Nov;99(11):582–591. [PubMed] [Google Scholar]
  11. Stehbens W. E. Chronic changes in the walls of experimentally produced aneurysms in sheep. Surg Gynecol Obstet. 1979 Jul;149(1):43–48. [PubMed] [Google Scholar]
  12. Stehbens W. E. Experimental production of aneurysms by microvascular surgery in rabbits. Vasc Surg. 1973 May-Jun;7(3):165–175. doi: 10.1177/153857447300700305. [DOI] [PubMed] [Google Scholar]
  13. Stehbens W. E. Haemodynamic production of lipid deposition, intimal teats, mural dissection and thrombosis in the blood vessel wall. Proc R Soc Lond B Biol Sci. 1974 Feb 12;185(1080):357–373. doi: 10.1098/rspb.1974.0024. [DOI] [PubMed] [Google Scholar]
  14. Stehbens W. E. The ultrastructure of experimental aneurysms in rabbits. Pathology. 1985 Jan;17(1):87–95. doi: 10.3109/00313028509063733. [DOI] [PubMed] [Google Scholar]
  15. Stehbens W. E. The ultrastructure of the anastomosed vein of experimental arteriovenous fistulae in sheep. Am J Pathol. 1974 Aug;76(2):377–400. [PMC free article] [PubMed] [Google Scholar]
  16. Stehbens W. E. Ultrastructure of aneurysms. Arch Neurol. 1975 Dec;32(12):798–807. doi: 10.1001/archneur.1975.00490540042005. [DOI] [PubMed] [Google Scholar]
  17. Vogel A., Holbrook K. A., Steinmann B., Gitzelmann R., Byers P. H. Abnormal collagen fibril structure in the gravis form (type I) of Ehlers-Danlos syndrome. Lab Invest. 1979 Feb;40(2):201–206. [PubMed] [Google Scholar]

Articles from International Journal of Experimental Pathology are provided here courtesy of Wiley

RESOURCES