Abstract
The intra-articular injection of iodoacetate into the knee joint of rats produced changes in the articular cartilage which resembled those of osteoarthritis. It caused virtually total loss of many of the oxidative enzymes, indicating inhibition of the main oxidative pathways. Treatment with an anti-rheumatic drug had little early effect but ultimately led to partial restoration of these pathways. The reduced progression of cartilage degradation induced by this drug was accompanied by some unusual histological features.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Buchmann U., Kalbhen D. A. Die tierexperimentelle Gonarthrose der Ratte und ihre Therapie mit Glykosaminoglykanpolysulfat (GAGPS). Z Rheumatol. 1985 May-Jun;44(3):100–107. [PubMed] [Google Scholar]
- Dunham J., Hoedt-Schmidt S., Kalbhen D. A. Structural and metabolic changes in articular cartilage induced by iodoacetate. Int J Exp Pathol. 1992 Aug;73(4):455–464. [PMC free article] [PubMed] [Google Scholar]
- Hoedt-Schmidt S., Scheid A., Kalbhen D. A. Histomorphological and lectin-histochemical confirmation of the antidegenerative effect of diclofenac in experimental osteoarthrosis. Arzneimittelforschung. 1989 Oct;39(10):1212–1219. [PubMed] [Google Scholar]
- Kalbhen D. A., Blum U. Theoretisches Konzept und experimentell Bestätigung für ein neues Arthrose-Modell am Versuchstier. Arzneimittelforschung. 1977;27(3):527–531. [PubMed] [Google Scholar]
- Kalbhen D. A., Scherbach E., Felten K. Histological investigations of the antiarthrotic effect of tribenoside (Glyvenol) in experimental osteoarthrosis. J Rheumatol. 1983 Apr;10(2):267–281. [PubMed] [Google Scholar]
- Scott J. E., Dorling J. Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions. Histochemie. 1965 Oct 1;5(3):221–233. doi: 10.1007/BF00306130. [DOI] [PubMed] [Google Scholar]