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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1993 Oct;74(5):501–509.

The induction of mitochondrial myopathy in the rat by feeding beta-guanidinopropionic acid and the reversibility of the induced mitochondrial lesions: a biochemical and ultrastructural investigation.

V De Tata 1, G Cavallini 1, M Pollera 1, Z Gori 1, E Bergamini 1
PMCID: PMC2002185  PMID: 8217785

Abstract

The long-lasting depletions of creatine phosphate induced by feeding rats with a beta-guanidinopropionic acid (GPA)-supplemented diet induces specific mitochondrial alterations in skeletal muscles very similar to those observed in human mitochondrial myopathies. The slow-twitch soleus muscle appears to be affected primarily, while the fast-twitch extensor digitorum longus is affected less severely and only after a longer period of treatment (6 months). Changes in the enzyme activities of glucose metabolism appear to be secondary and differ between the two muscles. Withdrawal of GPA from the diet after 2 months of treatment shows that both mitochondrial alterations and biochemical modification are reversible.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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