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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1990 Aug;71(4):433–440.

Protection against endotoxin-induced foetal resorption in mice by desferrioxamine and ebselen.

J D Gower 1, R J Baldock 1, A M O'Sullivan 1, C J Doré 1, C R Coid 1, C J Green 1
PMCID: PMC2002279  PMID: 2205283

Abstract

Endotoxin was administered to mice on their 13th day of pregnancy at doses which caused the resorption of approximately 50% of the implanted foetuses. The iron chelator desferrioxamine was found to significantly inhibit the percentage of resorptions induced by endotoxin in a dose-dependent manner. The highest dose of desferrioxamine (5 mg) given intravenously 30 min prior to, immediately after, and 4 and 24 h after endotoxin inoculation, reduced the percentage of resorptions from 56.9 to 17.9%. Administration of the novel selenium-containing compound ebselen, which is both an antioxidant and an inhibitor of leukotriene synthesis, was also found to significantly protect against endotoxin-induced foetal resorptions, reducing the percentage of resorbed foetuses from 52.9 to 26.0% when given at a dose of 50 mg/kg (s.c.) at the time of endotoxin inoculation and 24 and 48 h following. Both these compounds also significantly reduced the increase in spleen weights observed when the mice were given endotoxin. These results provide evidence that the iron-catalysed production of hydroxyl radicals from other oxygen-derived species and the formation of leukotrienes play an important role in the mechanism by which endotoxin causes foetal resorptions in the mouse.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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