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International Journal of Experimental Pathology logoLink to International Journal of Experimental Pathology
. 1990 Aug;71(4):557–571.

Cytomegalovirus infection of adipose tissues induces steatitis in adult mice.

P Price 1, K S Eddy 1, J M Papadimitriou 1, T A Robertson 1, G R Shellam 1
PMCID: PMC2002283  PMID: 2169300

Abstract

Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. More infected cells were detected in C3H mice than in BALB/c, BALB.B, BALB.K or C57BL/6 mice. Peripancreatic steatitis consisted of a monocytic infiltrate surrounding focal necrosis of adipocytes, the severity of which was influenced by the route of inoculation, virus dose, and genetic susceptibility to disseminated MCMV-disease. C57BL/6 mice showed the greatest susceptibility with severe coalescing focal inflammation around areas of coagulative necrosis. Salivary gland adipose tissues exhibited lymphocytic steatitis, which was reduced in Nu/Nu mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apperley J. F., Dowding C., Hibbin J., Buiter J., Matutes E., Sissons P. J., Gordon M., Goldman J. M. The effect of cytomegalovirus on hemopoiesis: in vitro evidence for selective infection of marrow stromal cells. Exp Hematol. 1989 Jan;17(1):38–45. [PubMed] [Google Scholar]
  2. Bartholomaeus W. N., O'Donoghue H., Foti D., Lawson C. M., Shellam G. R., Reed W. D. Multiple autoantibodies following cytomegalovirus infection: virus distribution and specificity of autoantibodies. Immunology. 1988 Jul;64(3):397–405. [PMC free article] [PubMed] [Google Scholar]
  3. Bruggeman C. A., Bruning J. H., Grauls G., van den Bogaard A. E., Bosman F. Presence of cytomegalovirus in brown fat. Study in a rat model. Intervirology. 1987;27(1):32–37. doi: 10.1159/000149712. [DOI] [PubMed] [Google Scholar]
  4. Chalmer J. E., Mackenzie J. S., Stanley N. F. Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse. J Gen Virol. 1977 Oct;37(1):107–114. doi: 10.1099/0022-1317-37-1-107. [DOI] [PubMed] [Google Scholar]
  5. Grundy J. E., Melief C. J. Effect of Nu/Nu gene on genetically determined resistance to murine cytomegalovirus. J Gen Virol. 1982 Jul;61(Pt 50):133–136. doi: 10.1099/0022-1317-61-1-133. [DOI] [PubMed] [Google Scholar]
  6. Harnett G. B., Shellam G. R. Variation in murine cytomegalovirus replication in fibroblasts from different mouse strains in vitro: correlation with in vivo resistance. J Gen Virol. 1982 Sep;62(Pt 1):39–47. doi: 10.1099/0022-1317-62-1-39. [DOI] [PubMed] [Google Scholar]
  7. Hashimoto I., Tomita M., Kohara T., Uchino I., Harasima A. Steatitis in mice infected with Coxsackie virus B3. Microbiol Immunol. 1985;29(4):371–376. doi: 10.1111/j.1348-0421.1985.tb00836.x. [DOI] [PubMed] [Google Scholar]
  8. Lawson C. M., O'Donoghue H., Bartholomaeus W. N., Reed W. D. Genetic control of mouse cytomegalovirus-induced myocarditis. Immunology. 1990 Jan;69(1):20–26. [PMC free article] [PubMed] [Google Scholar]
  9. Lawson C. M., O'Donoghue H., Reed W. D. The role of T cells in mouse cytomegalovirus myocarditis. Immunology. 1989 May;67(1):132–134. [PMC free article] [PubMed] [Google Scholar]
  10. Mercer J. A., Spector D. H. Pathogenesis of acute murine cytomegalovirus infection in resistant and susceptible strains of mice. J Virol. 1986 Feb;57(2):497–504. doi: 10.1128/jvi.57.2.497-504.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mims C. A., Gould J. Splenic necrosis in mice infected with cytomegalovirus. J Infect Dis. 1978 May;137(5):587–591. doi: 10.1093/infdis/137.5.587. [DOI] [PubMed] [Google Scholar]
  12. Price P., Winter J. G., Nikoletti S., Hudson J. B., Shellam G. R. Functional changes in murine macrophages infected with cytomegalovirus relate to H-2-determined sensitivity to infection. J Virol. 1987 Nov;61(11):3602–3606. doi: 10.1128/jvi.61.11.3602-3606.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Price P., Winter J. G., Shellam G. R. Genetically determined resistance to murine cytomegalovirus: a role for lymphocytostatic macrophages. J Gen Virol. 1987 Dec;68(Pt 12):2997–3008. doi: 10.1099/0022-1317-68-12-2997. [DOI] [PubMed] [Google Scholar]
  14. Schmidt H., Lankisch P. G. Fat necrosis - a cause of pancreatic parenchymal necrosis? Digestion. 1978;17(1):84–91. doi: 10.1159/000198097. [DOI] [PubMed] [Google Scholar]
  15. Shanley J. D. Host genetic factors influence murine cytomegalovirus lung infection and interstitial pneumonitis. J Gen Virol. 1984 Dec;65(Pt 12):2121–2128. doi: 10.1099/0022-1317-65-12-2121. [DOI] [PubMed] [Google Scholar]

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