Abstract
The chemically induced injury to articular cartilage, caused by two successive intra-articular injections of sodium iodoacetate, has been used in studies on the effects of anti-inflammatory and of potentially chondroprotective agents. It has been assumed that the injurious effects are caused by inhibition of the glycolytic pathway. In the present study this inhibition has been shown to be greater than expected from in vitro studies, and to influence equally other oxidative pathways. However, the response is clearly not a simple one in that some of the surface chondrocytes, and synovial lining cells in close proximity to the cartilage, show virtually no inhibition.
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- Dunham J., Shackleton D. R., Bitensky L., Chayen J., Billingham M. E., Muir I. H. Enzymic heterogeneity of normal canine articular cartilage. Cell Biochem Funct. 1986 Jan;4(1):43–46. doi: 10.1002/cbf.290040107. [DOI] [PubMed] [Google Scholar]
- Greenhouse W. V., Lehninger A. L. Magnitude of malate-aspartate reduced nicotinamide adenine dinucleotide shuttle activity in intact respiring tumor cells. Cancer Res. 1977 Nov;37(11):4173–4181. [PubMed] [Google Scholar]
- Kalbhen D. A., Blum U. Theoretisches Konzept und experimentell Bestätigung für ein neues Arthrose-Modell am Versuchstier. Arzneimittelforschung. 1977;27(3):527–531. [PubMed] [Google Scholar]
- Moreadith R. W., Lehninger A. L. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem. 1984 May 25;259(10):6215–6221. [PubMed] [Google Scholar]
- Scott J. E., Dorling J. Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions. Histochemie. 1965 Oct 1;5(3):221–233. doi: 10.1007/BF00306130. [DOI] [PubMed] [Google Scholar]
- Williams J. M., Brandt K. D. Benoxaprofen reduces osteophyte formation and fibrillation after articular cartilage injury. J Rheumatol. 1985 Feb;12(1):27–32. [PubMed] [Google Scholar]