Abstract
Two P388 cell lines with acquired resistance to daunorubicin have been shown to exhibit cross-resistance to anthrapyrazolone (NSC 357885). The degree of cross-resistance observed in these cell lines (58 and 150 fold) is similar to those observed towards daunorubicin (34 and 142 fold). However the decreased drug accumulation observed for daunorubicin in the resistant cell lines (4-6 fold) is not observed for anthrapyrazolone. Similarly, verapamil can increase daunorubicin accumulation in resistant cells but has no effect on anthrapyrazolone accumulation. It is concluded that in contrast to daunorubicin, decreased anthrapyrazolone accumulation is not the resistance mechanism operative in daunorubicin resistant cell lines towards anthrapyrazolone.
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Selected References
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- Capranico G., Dasdia T., Zunino F. Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells. Int J Cancer. 1986 Feb 15;37(2):227–231. doi: 10.1002/ijc.2910370210. [DOI] [PubMed] [Google Scholar]
- Capranico G., Soranzo C., Zunino F. Single-strand DNA breaks induced by chromophore-modified anthracyclines in P388 leukemia cells. Cancer Res. 1986 Nov;46(11):5499–5503. [PubMed] [Google Scholar]
- Dano K. Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo. Cancer Chemother Rep. 1972 Dec;56(6):701–708. [PubMed] [Google Scholar]
- Danø K., Skovsgaard T., Nissen N. I., Friche E., Di Marco A. Mechanism of resistance to anthracyclines and vinca alkaloids. Prog Clin Biol Res. 1983;132C:231–246. [PubMed] [Google Scholar]
- Klohs W. D., Steinkampf R. W., Havlick M. J., Jackson R. C. Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists. Cancer Res. 1986 Sep;46(9):4352–4356. [PubMed] [Google Scholar]
- McGown A. T., Ward T. H., Fox B. W. Comparative studies of the uptake of daunorubicin in sensitive and resistant P388 cell lines by flow cytometry and biochemical extraction procedures. Cancer Chemother Pharmacol. 1983;11(2):113–116. doi: 10.1007/BF00254258. [DOI] [PubMed] [Google Scholar]
- Showalter H. D., Johnson J. L., Werbel L. M., Leopold W. R., Jackson R. C., Elslager E. F. 5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation. J Med Chem. 1984 Mar;27(3):253–255. doi: 10.1021/jm00369a002. [DOI] [PubMed] [Google Scholar]