Abstract
We report 2 cases of hypersensitivity to an epinephrine preparation in local anesthetics which were found by skin tests for local anesthetics. Both patients had uncomfortable episodes to local anesthetics at dental treatment. In both cases, the skin tests showed positive reactions to 2% lidocaine with 1:80,000 epinephrine. Furthermore drug lymphocyte stimulation test revealed positive reaction to epinephrine hydrochloride, epinephrine bitartrate in case 1, whereas in case 2, the drug lymphocyte stimulation test showed positive response to epinephrine bitartrate. Attention should be paid to exogenous epinephrine preparations that have the potential to induce hypersensitivity during dental treatment.
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Selected References
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- Alani S. D., Alani M. D. Allergic contact dermatits and conjunctivitis from epinephrine. Contact Dermatitis. 1976 Jun;2(3):147–150. doi: 10.1111/j.1600-0536.1976.tb03014.x. [DOI] [PubMed] [Google Scholar]
- Fischman S. L. Dental management of the medically disabled adult. J Can Dent Assoc. 1981 Oct;47(10):643–648. [PubMed] [Google Scholar]
- Gaspari A. A. Contact allergy to ophthalmic dipivalyl epinephrine hydrochloride: demonstration by patch testing. Contact Dermatitis. 1993 Jan;28(1):35–37. doi: 10.1111/j.1600-0536.1993.tb03321.x. [DOI] [PubMed] [Google Scholar]
- Gibbs R. C. Allergic contact dermatitis to epinephrine. Arch Dermatol. 1970 Jan;101(1):92–94. [PubMed] [Google Scholar]
- Pérusse R., Goulet J. P., Turcotte J. Y. Contraindications to vasoconstrictors in dentistry: Part I. Cardiovascular diseases. Oral Surg Oral Med Oral Pathol. 1992 Nov;74(5):679–686. doi: 10.1016/0030-4220(92)90365-w. [DOI] [PubMed] [Google Scholar]
- Yoshimura T., Kurita C., Yamazaki F., Nakano S., Nagai H. Lymphocyte stimulation test with tetrazolium-based colorimetric assay for diagnosis of drug-induced allergic hepatitis. Biol Pharm Bull. 1994 Jul;17(7):921–926. doi: 10.1248/bpb.17.921. [DOI] [PubMed] [Google Scholar]