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. 1972 Apr;26(2):120–128. doi: 10.1038/bjc.1972.18

Sarcoid Reactions and Sarcoidosis in Hodgkin's Disease and Other Malignant Lymphomata

Hans Brincker
PMCID: PMC2008429  PMID: 5038325

Abstract

Nineteen cases of malignant lymphomata were selected for study from a group of about 1500 collected cases of malignant lymphomata because they showed histological evidence of non-infectious epithelioid-cell granulomata in one or more tissues.

In the 19 cases selected, 5 cases of systemic sarcoidosis, 4 cases of an associated malignancy, 1 pre-malignant condition, and 1 case of an auto-immune disease were found.

This remarkable association of sarcoid reactions or sarcoidosis with malignant lymphomata and associated malignancies seems to justify speculation on the possibility of a common aetiological factor, e.g. in the form of an altered immune reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atwood W. G., Miller R. C., Nelson C. T. Sarcoidosis and the malignant lymphoreticular diseases. Arch Dermatol. 1966 Aug;94(2):144–151. [PubMed] [Google Scholar]
  2. BUCKLE R. M. Reticulosarcoma complicating sarcoidosis. Tubercle. 1960 Jun;41:213–215. doi: 10.1016/s0041-3879(60)80081-5. [DOI] [PubMed] [Google Scholar]
  3. Chase M. W. Delayed-type hypersensitivity and the immunology of Hodgkin's disease, with a parallel examination of sarcoidosis. Cancer Res. 1966 Jun;26(6):1097–1120. [PubMed] [Google Scholar]
  4. Doll R., Kinlen L. Immunosurveillance and cancer: epidemiological evidence. Br Med J. 1970 Nov 14;4(5732):420–422. doi: 10.1136/bmj.4.5732.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GORTON G., LINELL F. Malignant tumours and sarcoid reactions in regional lymph nodes. Acta radiol. 1957 May;47(5):381–392. doi: 10.3109/00016925709170911. [DOI] [PubMed] [Google Scholar]
  6. Goldfarb B. L., Cohen S. S. Coexistent disseminated sarcoidosis and Hodgkin's disease. JAMA. 1970 Mar 2;211(9):1525–1528. [PubMed] [Google Scholar]
  7. HERBEUVAL R., LAMY P., CUNY G., PIERSON B., GILGENKRANTZ J. M., CHERRIER F. [Apropos of 3 cases of Hodgkin's disease with atypical onset. Relation to Besnier-Boeck-Schaumann disease]. Rev Med Nancy. 1960 Aug-Sep;85:762–771. [PubMed] [Google Scholar]
  8. Horwitz O., Payne P. G., Wilbek E. Epidemiology of sarcoidosis in Denmark. Dan Med Bull. 1967 Jun;14(7):178–182. [PubMed] [Google Scholar]
  9. KISSEL P., DUREUX J. B., RAUBER G., BEUREY J., PETERS A., ANTHOINE D. [Malignant reticulosis and sarcoidosis. Apropos of a case of malignant lymphoreticulosis with histopathological lymph node images of the sarcoid type. Terminal blood invasion by cells of lymphoid aspect]. Ann Med Nancy. 1962 May;1:167–176. [PubMed] [Google Scholar]
  10. Kadin M. E., Donaldson S. S., Dorfman R. F. Isolated granulomas in Hodgkin's disease. N Engl J Med. 1970 Oct 15;283(16):859–861. doi: 10.1056/NEJM197010152831609. [DOI] [PubMed] [Google Scholar]
  11. Keast D. Immunosurveillance and cancer. Lancet. 1970 Oct 3;2(7675):710–712. doi: 10.1016/s0140-6736(70)91973-2. [DOI] [PubMed] [Google Scholar]
  12. LAMACHE A., CHEVREL M. L., BOUREL M., RICHIER J. L. Poussée maligne mortelle, après traitement cortisonique au cours d'une réticulose à type de sarcoïdose. Bull Mem Soc Med Hop Paris. 1954 Nov 5;70(28-29):1070–1080. [PubMed] [Google Scholar]
  13. LEA A. J. AN ASSOCIATION BETWEEN THE RHEUMATIC DISEASES AND THE RETICULOSES. Ann Rheum Dis. 1964 Nov;23:480–484. doi: 10.1136/ard.23.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lynch H. T. Skin, heredity, and cancer. Cancer. 1969 Aug;24(2):277–288. doi: 10.1002/1097-0142(196908)24:2<277::aid-cncr2820240211>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  15. MOERTEL C. G., DOCKERTY M. B., BAGGENSTOSS A. H. Multiple primary malignant neoplasms. I. Introduction and presentation of data. Cancer. 1961 Mar-Apr;14:221–230. doi: 10.1002/1097-0142(196103/04)14:2<221::aid-cncr2820140202>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  16. NADEL E. M., ACKERMAN L. V. Lesions resembling Boeck's sarcoid in lymph nodes draining an area containing a malignant neoplasm. Am J Clin Pathol. 1950 Oct;20(10):952–957. doi: 10.1093/ajcp/20.10.952. [DOI] [PubMed] [Google Scholar]
  17. Nilsen L. B., Missal M. E., Condemi J. J. Appearance of Hodgkin's disease in a patient with systemic lupus erythematosus. Cancer. 1967 Nov;20(11):1930–1933. doi: 10.1002/1097-0142(196711)20:11<1930::aid-cncr2820201121>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  18. PETTET J. D., PEASE G. L., COOPER T. An evaluation of paraffin sections of aspirated bone marrow in malignant lymphomas. Blood. 1955 Aug;10(8):820–830. [PubMed] [Google Scholar]
  19. Silver H. M., Nachnani G., Breslow A. Lymphosarcoma and sarcoidosis. Am Rev Respir Dis. 1967 Aug;96(2):290–295. doi: 10.1164/arrd.1967.96.2.290. [DOI] [PubMed] [Google Scholar]
  20. Symmers W. S. Localized Tuberculoid Granulomas Associated with Carcinoma: Their Relationship to Sarcoidosis. Am J Pathol. 1951 Jun;27(3):493–521. [PMC free article] [PubMed] [Google Scholar]
  21. Talal N., Sokoloff L., Barth W. F. Extrasalivary lymphoid abnormalities in Sjögren's syndrome (reticulum cell sarcoma, "pseudolymphoma," macroglobulinemia). Am J Med. 1967 Jul;43(1):50–65. doi: 10.1016/0002-9343(67)90148-9. [DOI] [PubMed] [Google Scholar]
  22. WILLIAMS R. C., Jr Dermatomyositis and malignancy: a review of the literature. Ann Intern Med. 1959 May;50(5):1174–1181. doi: 10.7326/0003-4819-50-5-1174. [DOI] [PubMed] [Google Scholar]

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