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. 1972 Apr;26(2):99–107. doi: 10.1038/bjc.1972.15

Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments

D N Wheatley, M E Gerrard, I R Kernohan, A R Currie
PMCID: PMC2008441  PMID: 4624907

Abstract

Further investigations into the mechanism by which CCl4 administration to Sprague-Dawley rats protects them against the adrenocorticolytic action of dimethylbenz(a)anthracene (DMBA) are reported. The results show that CCl4 must be given shortly before DMBA to achieve the best protection and that treatments given after DMBA are ineffective. It was established that the hepatotoxicity of CCl4 in these experiments was related reciprocally to the adrenocorticolytic effect of DMBA.

Protection with butter yellow (DAB) was achieved only when sufficient time elapses for drug metabolism to be stimulated in the liver. Butter yellow given after DMBA has no protective effect but the prior exposure of the rats to DMBA potentiates the hepatotoxic effects of DAB.

Partial hepatectomy gives protection when performed 1 day before DMBA; shorter intervals give no protection. Some protection can be achieved with resection 6 or 24 hours after DMBA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyland E., Sims P., Huggins C. Induction of adrenal damage and cancer with metabolites of 7,12-dimethylbenz(a)anthracene. Nature. 1965 Aug 21;207(999):816–817. doi: 10.1038/207816b0. [DOI] [PubMed] [Google Scholar]
  2. FOUTS J. R., DIXON R. L., SHULTICE R. W. The metabolism of drugs by regenerating liver. Biochem Pharmacol. 1961 Aug;7:265–270. doi: 10.1016/0006-2952(61)90093-4. [DOI] [PubMed] [Google Scholar]
  3. Garner R. C., McLean A. E. Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone. Biochem Pharmacol. 1969 Mar;18(3):645–650. doi: 10.1016/0006-2952(69)90089-6. [DOI] [PubMed] [Google Scholar]
  4. Recknagel R. O., Ghoshal A. K. Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity. Lab Invest. 1966 Jan;15(1 Pt 1):132–148. [PubMed] [Google Scholar]
  5. Slater T. F. Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation. Nature. 1966 Jan 1;209(5018):36–40. doi: 10.1038/209036a0. [DOI] [PubMed] [Google Scholar]
  6. Smuckler E. A., Hultin T. Effects of SKF 525-A and adrenalectomy on the amino acid incorporation by rat liver microsomes from normal and CCl-4-treated rats. Exp Mol Pathol. 1966 Oct;5(5):504–515. doi: 10.1016/0014-4800(66)90029-3. [DOI] [PubMed] [Google Scholar]
  7. Wheatley D. N., Hamilton A. G., Currie A. R., Boyland E., Sims P. Adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and its prevention. Nature. 1966 Sep 17;211(5055):1311–1312. doi: 10.1038/2111311a0. [DOI] [PubMed] [Google Scholar]
  8. Wheatley D. N., Kernohan I. R., Currie A. R. Liver injury and the prevention of massive adrenal necrosis from 9, 10-dimethyl-1,2-benzanthracene in rats. Nature. 1966 Jul 23;211(5047):387–389. doi: 10.1038/211387a0. [DOI] [PubMed] [Google Scholar]

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