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. 1971 Jun;25(2):365–376. doi: 10.1038/bjc.1971.47

Albumin Metabolism in Rabbits and Rats with Transplanted Tumours

E P Wraight
PMCID: PMC2008445  PMID: 5115834

Abstract

Albumin distributions and turnover rates have been studied using 131I labelled tracer material in rabbits with Vx2 carcinoma and rats bearing SP7 fibrosarcoma in comparison with control animals. Albumin concentrations were reduced in the tumour bearing animals but plasma volumes increased as the tumours developed. Relative increases were seen in the extravascular distribution of albumin, due partly to albumin pooling in and around the tumours and possibly also to general increases in capillary permeability. In the rats there was a considerable increase in the catabolic rate of albumin which was not related to urinary protein loss. The tumour bearing rabbits showed evidence both of increased catabolism and of decreased synthesis and the combination of the two effects resulted in a greater lowering of albumin concentration than was seen in the rats. Possible mechanisms for these findings and their significance in human malignant disease are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BABSON A. L. The rate of loss of labeled plasma proteins from the circulation of tumor-bearing rats. Biochim Biophys Acta. 1956 May;20(2):418–418. doi: 10.1016/0006-3002(56)90320-1. [DOI] [PubMed] [Google Scholar]
  2. BATEMAN J. C. A study of blood volume and anemia in cancer patients. Blood. 1951 Jul;6(7):639–651. [PubMed] [Google Scholar]
  3. BERLIN N. I., HYDE G. M., PARSONS R. J., LAWRENCE J. H. The blood volume in cancer. Cancer. 1955 Jul-Aug;8(4):796–802. doi: 10.1002/1097-0142(1955)8:4<796::aid-cncr2820080425>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  4. BLAKELEY W. R., BENNETT L. R., MALONEY J. V., Jr An evaluation of preoperative blood volume determination in the debilitated surgical patient. Surg Gynecol Obstet. 1962 Sep;115:257–265. [PubMed] [Google Scholar]
  5. Banerjee R. N., Narang R. M. Haematological changes in malignancy. Br J Haematol. 1967 Nov;13(6):829–843. doi: 10.1111/j.1365-2141.1967.tb08854.x. [DOI] [PubMed] [Google Scholar]
  6. Corradi C., Curti B., Agostoni A., Torretta A. La permeabilità capillare alla siero-albumina 131 I nei soggetti cancerosi prima e dopo telecobaltoterapia. Minerva Med. 1968 Apr 4;59(27):1523–1527. [PubMed] [Google Scholar]
  7. Dykes P. W. The rates of distribution and catabolism of albumin in normal subjects and in patients with cirrhosis of the liver. Clin Sci. 1968 Feb;34(1):161–183. [PubMed] [Google Scholar]
  8. GROSSMAN J., YALOW A. A., WESTON R. E. Albumin degradation and synthesis as influenced by hydrocortisone, corticotropin and infection. Metabolism. 1960 Jun;9:528–550. [PubMed] [Google Scholar]
  9. HENDERSON J. F., LEPAGE G. A. The nutrition of tumors: a review. Cancer Res. 1959 Oct;19:887–902. [PubMed] [Google Scholar]
  10. KAVETSKY R. E., SAMUNDGEAN E. M., BUTENKO Z. A. Changes in the functional state of the adrenal cortex during development of tumours. Acta Unio Int Contra Cancrum. 1962;18:115–117. [PubMed] [Google Scholar]
  11. KELLY K. H., BIERMAN H. R., SHIMKIN M. B. Blood volume, body water, and circulation time in patients with advanced neoplastic diseases. Cancer Res. 1952 Nov;12(11):814–817. [PubMed] [Google Scholar]
  12. Lichter I., Sirett N. E. Plasma cortisol levels in lung cancer. Br Med J. 1968 Apr 20;2(5598):154–156. doi: 10.1136/bmj.2.5598.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mouridsen H. T. Turnover of human serum albumin before and after operations. Clin Sci. 1967 Oct;33(2):345–354. [PubMed] [Google Scholar]
  14. ROTHSCHILD M. A., SCHREIBER S. S., ORATZ M., McGEE H. L. The effects of adrenocortical hormones on albumin metabolism studied with albumin-I 131. J Clin Invest. 1958 Sep;37(9):1229–1235. doi: 10.1172/JCI103711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reeve T. S., Vincent P. C., Brittle N., Nicholls A. Blood volume in malignant disease: case studies in 86 females. Aust N Z J Surg. 1968 Nov;38(2):158–168. [PubMed] [Google Scholar]
  16. Sterling K. THE EFFECT OF CUSHING'S SYNDROME UPON SERUM ALBUMIN METABOLISM. J Clin Invest. 1960 Dec;39(12):1900–1908. doi: 10.1172/JCI104214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. TAKEDA Y. HORMONAL EFFECTS ON METABOLISM AND DISTRIBUTION OF PLASMA ALBUMIN IN THE DOG. Am J Physiol. 1964 Jun;206:1229–1236. doi: 10.1152/ajplegacy.1964.206.6.1229. [DOI] [PubMed] [Google Scholar]
  18. Toporek M. Effect of perfusing blood on serum protein oduction by isolated perfused livers from normal or tumor-bearing rats. Cancer Res. 1969 Jun;29(6 Suppl):1267–1271. [PubMed] [Google Scholar]
  19. WALDMANN T., TRIER J., FALLON H. Albumin metabolism in patients with lymphoma. J Clin Invest. 1963 Feb;42:171–178. doi: 10.1172/JCI104703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WEBSTER D. A SIMPLE METHOD OF SERUM PROTEIN FRACTIONATION ON CELLULOSE ACETATE AND A COMPARISON OF THE ALBUMIN LEVELS WITH A METHOD OF SODIUM SULPHITE FRACTIONATION. Clin Chim Acta. 1965 Feb;11:101–112. doi: 10.1016/0009-8981(65)90202-0. [DOI] [PubMed] [Google Scholar]
  21. WERK E. E., Jr, SHOLITON L. J. Adrenocortical function in carcinoma of the lung. Cancer. 1960 May-Jun;13:469–481. doi: 10.1002/1097-0142(196005/06)13:3<469::aid-cncr2820130309>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  22. WETTERFORS J., LILJEDDAHL S. O., PLANTIN L. O., BIRKE G. Catabolism and distribution of albumin in gastric cancer. Acta Med Scand. 1962 Aug;172:163–186. doi: 10.1111/j.0954-6820.1962.tb07141.x. [DOI] [PubMed] [Google Scholar]
  23. Wraight E. P. The place of deconvolution analysis in plasma protein turnover studies. Phys Med Biol. 1969 Jul;14(3):463–470. doi: 10.1088/0031-9155/14/3/308. [DOI] [PubMed] [Google Scholar]

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