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. 1972 Jun;26(3):183–189. doi: 10.1038/bjc.1972.25

Metastatic Spread of Human Tumour Implanted into Thymectomized, Antithymocyte Serum Treated Hamsters

L M Cobb
PMCID: PMC2008479  PMID: 5047142

Abstract

The growth and metastatic spread of human tumours in immunosuppressed hamsters is described. A variety of human tumours were transplanted to the flank or the cheek pouch of the hamsters. Immunosuppression was obtained by combined thymectomy and ATS treatment. In the period up to 4 months after implantation, metastases to the lungs were observed with carcinomata of breast, colon, larynx and kidney; also melanoma, rhabdomyosarcoma, fibrosarcoma and teratoma of testis. Fourteen of 20 different tumours implanted metastasized to the lungs. Only 2 tumours, a hypernephroma and a melanoma, became established at the site of implantation; the remainder regressed even though the tumour was proliferating in the lungs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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