Abstract
Human experience of the toxicity of radium acts as a guide for the setting of occupationally permissible levels for radioactive nucleides, especially bone-seekers. Reviewing the published statements and photomicrographs in early reports especially those of Martland (1931) one can make a case that malignancy was induced in bone-marrow (leukaemia, malignant myelosclerosis) as well as in bone (osteosarcoma) by radium, especially with large doses. Three case reports of radium intoxication in Britons are noted as compatible with this suggestion, after revised interpretation in two of them.
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- ARDRAN G. M., KEMP F. H. Radium poisoning; two case reports. Br J Radiol. 1958 Nov;31(371):605–610. doi: 10.1259/0007-1285-31-371-605. [DOI] [PubMed] [Google Scholar]
- Evans R. D., Finkel A. J., Hasterlik R. J., Keane A. T., Kolenkow R. J., Neal W. R., Shanahan M. M. The risk of bone cancer in man from internally deposited radium. Br J Radiol. 1968 May;41(485):391–393. doi: 10.1259/0007-1285-41-485-391. [DOI] [PubMed] [Google Scholar]
- Hems G. The risk of bone cancer in man from internally deposited radium. Br J Radiol. 1967 Jul;40(475):506–511. doi: 10.1259/0007-1285-40-475-506. [DOI] [PubMed] [Google Scholar]
- LOONEY W. B., HASTERLIK R. J., BRUES A. M., SKIRMONT E. A clinical investigation of the chronic effects of radium salts administered therapeutically; 1915-1931. Am J Roentgenol Radium Ther Nucl Med. 1955 Jun;73(6):1006–1037. [PubMed] [Google Scholar]
- Szur L., Lewis S. M. The haematological complications of polycythaemia vera and treatment with radioactive phosphorus. Br J Radiol. 1966 Feb;39(458):122–130. doi: 10.1259/0007-1285-39-458-122. [DOI] [PubMed] [Google Scholar]