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. 1970 Jun;24(2):364–370. doi: 10.1038/bjc.1970.42

Diabetes and Growth of Tumour Transplants

Beryl M A Davies
PMCID: PMC2008574  PMID: 5451575

Abstract

Appreciable insulin occurred in transplants of a hamster and a mouse adrenal tumour. The hormone was measured by immunoassay. In hamster experiments, the weight of tumours grown in animals made mildly diabetic was five times less than those grown in controls. No insulin nor diabetic effect occurred in transplants of a mouse brain or stomach tumour.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEACONSFIELD P., LIUZZI A. The significance of glucose metabolism via the pentose phosphate pathway in animal tissue. Life Sci. 1963 Jul;(7):459–464. doi: 10.1016/0024-3205(63)90133-4. [DOI] [PubMed] [Google Scholar]
  2. Best C. H., Campbell J., Haist R. E. The effect of anterior pituitary extracts on the insulin content of the pancreas. J Physiol. 1939 Dec 14;97(2):200–206. doi: 10.1113/jphysiol.1939.sp003799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. LOWBEER L. Hypoglycemia-producing extrapancreatic neoplasms. A review. Am J Clin Pathol. 1961 Mar;35:233–243. doi: 10.1093/ajcp/35.3.233. [DOI] [PubMed] [Google Scholar]
  5. Morgan C. R., Lazarow A. Immunoassay of pancreatic and plasma insulin following alloxan injection of rats. Diabetes. 1965 Oct;14(10):669–671. doi: 10.2337/diab.14.10.669. [DOI] [PubMed] [Google Scholar]
  6. Rubenstein A. H., Steiner D. F., Cho S., Lawrence A. M., Kirsteins L. Immunological properties of bovine proinsulin and related fractions. Diabetes. 1969 Sep;18(9):598–605. doi: 10.2337/diab.18.9.598. [DOI] [PubMed] [Google Scholar]
  7. SAHASRABUDHE M. B., NERURKAR M. K., NARURKAR M. V., TILAK B. D., BHAVSAR M. D. Inhibition of tumour growth by interference of hexose mono-phosphate pathway. Synthesis and anticancer properties of thiophene 2 : 5 dicarboxylic acid. Br J Cancer. 1960 Sep;14:547–554. doi: 10.1038/bjc.1960.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Sodoyez J. C., Luyckx A. S., Lefebvre P. J. Biological properties of a transplantable islet-cell tumor of the golden hamster. II. Insulin content of the tumor and some metabolic characteristics of the tumor-bearing animals. Diabetes. 1967 Jun;16(6):415–417. doi: 10.2337/diab.16.6.415. [DOI] [PubMed] [Google Scholar]
  9. WEINHOUSE S., WENNER C. E. Metabolism of neoplastic tissue. IX. An isotope tracer study of glucose catabolism pathways in normal and neoplastic tissues. J Biol Chem. 1956 Sep;222(1):399–414. [PubMed] [Google Scholar]

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