Abstract
Circulating antibody response to flagella antigen has been measured in three groups of Sprague-Dawley rats after feeding with 7.12.DMBA in an attempt to differentiate carcinogen and tumour growth as causative agents in the depression of immune response seen in these animals. DMBA fed female rats developing tumours had progressive depression of both primary and secondary response as compared to control animals, and 7S and 19S antibody fractions were equally affected. Removal of tumours did not result in recovery of response. Attempts to prevent tumour development by mammectomy after DMBA feeding were unsuccessful, but the similar number of tumours found in this group was associated with an equal degree of antibody depression to that seen in the first experiment. Male animals fed DMBA did not develop malignant tumours, and showed no depression of immune response. Results suggest that tumour development plays a part in the depression of circulating antibody response seen in these animals, but that it is not directly related to the number of tumours, and is not reversible by tumour excision.
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- ADA G. L., NOSSAL G. J., PYE J., ABBOT A. ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE. Aust J Exp Biol Med Sci. 1964 Jun;42:267–282. [PubMed] [Google Scholar]
- Allison A. C., Law L. W. Effects of antilymphocyte serum on virus oncogenesis. Proc Soc Exp Biol Med. 1968 Jan;127(1):207–212. doi: 10.3181/00379727-127-32657. [DOI] [PubMed] [Google Scholar]
- BURNET M. IMMUNOLOGICAL FACTORS IN THE PROCESS OF CARCINOGENESIS. Br Med Bull. 1964 May;20:154–158. doi: 10.1093/oxfordjournals.bmb.a070310. [DOI] [PubMed] [Google Scholar]
- Brunschwig A., Southam C. M., Levin A. G. Host resistance to cancer. Clinical experiments by homotransplants, autotransplants and admixture of autologous leucocytes. Ann Surg. 1965 Sep;162(3):416–425. doi: 10.1097/00000658-196509000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ceglowski W. S., Friedman H. Immunosuppressive effects of Friend and Rauscher leukemia disease viruses on cellular and humoral antibody formation. J Natl Cancer Inst. 1968 May;40(5):983–995. [PubMed] [Google Scholar]
- Hughes L. E., Mackay W. D. Suppression of the tuberculin response in malignant disease. Br Med J. 1965 Dec 4;2(5474):1346–1348. doi: 10.1136/bmj.2.5474.1346. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krant M. J., Manskopf G., Brandrup C. S., Madoff M. A. Immunologic alterations in bronchogenic cancer. Sequential study. Cancer. 1968 Apr;21(4):623–631. doi: 10.1002/1097-0142(196804)21:4<623::aid-cncr2820210414>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- MILLER J. F., GRANT G. A., ROE F. J. EFFECT OF THYMECTOMY ON THE INDUCTION OF SKIN TUMOURS BY 3,4-BENZOPYRENE. Nature. 1963 Aug 31;199:920–922. doi: 10.1038/199920a0. [DOI] [PubMed] [Google Scholar]
- Southam C. M. The immunologic status of patients with nonlymphomatous cancer. Cancer Res. 1968 Jul;28(7):1433–1440. [PubMed] [Google Scholar]
- Stjernswärd J. Effect of noncarcinogenic and carcinogenic hydrocarbons on antibody-forming cells measured at the cellular level in vitro. J Natl Cancer Inst. 1966 Jun;36(6):1189–1195. [PubMed] [Google Scholar]
- YOUNG S., COWAN D. M., SUTHERLAND L. E. The histology of induced mammary tumours in rats. J Pathol Bacteriol. 1963 Apr;85:331–340. doi: 10.1002/path.1700850210. [DOI] [PubMed] [Google Scholar]