Abstract
The effect of the progestogen medroxyprogesterone acetate on metastases from renal, endometrial and other tumours has been studied in 25 patients. Seven patients with renal and endometrial tumours had a useful response, pulmonary metastases and a large primary renal tumour showing the greatest effect. Bony metastases were unaffected by the drug and were treated by local radiotherapy. If a response occurred, it did so within 3 months.
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- BLOOM H. J., DUKES C. E., MITCHLEY B. C. HORMONE-DEPENDENT TUMOURS OF THE KIDNEY. I. THE OESTROGEN-INDUCED RENAL TUMOUR OF THE SYRIAN HAMSTER. HORMONE TREATMENT AND POSSIBLE RELATIONSHIP TO CARCINOMA OF THE KIDNEY IN MAN. Br J Cancer. 1963 Dec;17:611–645. doi: 10.1038/bjc.1963.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLOOM H. J., WALLACE D. M. HORMONES AND THE KIDNEY: POSSIBLE THERAPEUTIC ROLE OF TESTOSTERONE IN A PATIENT WITH REGRESSION OF METASTASES FROM RENAL ADENOCARCINOMA. Br Med J. 1964 Aug 22;2(5407):476–480. doi: 10.1136/bmj.2.5407.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HORNING E. S., WHITTICK J. W. The histogenesis of stilboestrol-induced renal tumours in the male golden hamster. Br J Cancer. 1954 Sep;8(3):451–457. doi: 10.1038/bjc.1954.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jenkin R. D. Androgens in metastatic renal adenocarcinoma. Br Med J. 1967 Feb 11;1(5536):361–361. doi: 10.1136/bmj.1.5536.361-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Samuels M. L., Sullivan P., Howe C. D. Medroxyprogesterone acetate in the treatment of renal cell carcinoma (hypernephroma). Cancer. 1968 Sep;22(3):525–532. doi: 10.1002/1097-0142(196809)22:3<525::aid-cncr2820220306>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Smith J. P., Rutledge F., Soffar S. W. Progestins in the treatment of patients with endometrial adenocarcinoma. Am J Obstet Gynecol. 1966 Apr 1;94(7):977–984. doi: 10.1016/0002-9378(66)90036-6. [DOI] [PubMed] [Google Scholar]




