Abstract
Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the treated mice were studied. In the 17-month-old group, 12 out of 13 treated mice developed hepatomas.
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- CERIOTTI G. A microchemical determination of desoxyribonucleic acid. J Biol Chem. 1952 Sep;198(1):297–303. [PubMed] [Google Scholar]
- Fitzhugh O. G., Nelson A. A. Liver Tumors in Rats Fed Thiourea or Thioacetamide. Science. 1948 Dec 3;108(2814):626–628. doi: 10.1126/science.108.2814.626. [DOI] [PubMed] [Google Scholar]
- Hruban Z., Gradman W., Slesers A., Lubran M. Toxicity of thioacetamide. Lab Invest. 1966 Nov;15(11):1748–1760. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- MIYAZAKI H., WADA A., TAKAYANAGI H. Histological studies of liver cirrhosis in white rats by thioacetamide feeding. Gan. 1956 Dec;47(3-4):805–807. [PubMed] [Google Scholar]
- OGUR M., ROSEN G. The nucleic acids of plant tissues; the extraction and estimation of desoxypentose nucleic acid and pentose nucleic acid. Arch Biochem. 1950 Feb;25(2):262–276. [PubMed] [Google Scholar]