Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1972 Oct;26(5):335–355. doi: 10.1038/bjc.1972.45

Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review.

D J Laurence, A M Neville
PMCID: PMC2008636  PMID: 4343676

Full text

PDF
335

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELEV G. I., PEROVA S. D., KHRAMKOVA N. I., POSTNIKOVA Z. A., IRLIN I. S. Production of embryonal alpha-globulin by transplantable mouse hepatomas. Transplantation. 1963 Apr;1:174–180. doi: 10.1097/00007890-196301020-00004. [DOI] [PubMed] [Google Scholar]
  2. Abelev G. I. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res. 1971;14:295–358. doi: 10.1016/s0065-230x(08)60523-0. [DOI] [PubMed] [Google Scholar]
  3. Abelev G. I., Bakirov R. D. Sintez émbrional'nykh antigenov syvorotki pechen'iu in vitro. Vopr Med Khim. 1967 Jul-Aug;13(4):378–383. [PubMed] [Google Scholar]
  4. Abelev G. I. Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data. Cancer Res. 1968 Jul;28(7):1344–1350. [PubMed] [Google Scholar]
  5. Alexander P. Foetal "antigens" in cancer. Nature. 1972 Jan 21;235(5334):137–140. doi: 10.1038/235137a0. [DOI] [PubMed] [Google Scholar]
  6. Alpert E., Pinn V. W., Isselbacher K. J. Alpha-fetoprotein in a patient with gastric carcinoma metastatic to the liver. N Engl J Med. 1971 Nov 4;285(19):1058–1059. doi: 10.1056/NEJM197111042851905. [DOI] [PubMed] [Google Scholar]
  7. BENNHOLD H., KALLEE E. Comparative studies on the half-life of I 131-labeled albumins and nonradioactive human serum albumin in a case of analbuminemia. J Clin Invest. 1959 May;38(5):863–872. doi: 10.1172/JCI103868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. BERGMANN F. H., LEVINE L., SPIRO R. G. Fetuin: immunochemistry and quantitative estimation in serum. Biochim Biophys Acta. 1962 Mar 26;58:41–51. doi: 10.1016/0006-3002(62)90815-6. [DOI] [PubMed] [Google Scholar]
  9. BROBERGER O., PERLMANN P. Autoantibodies in human ulcerative colitis. J Exp Med. 1959 Nov 1;110:657–674. doi: 10.1084/jem.110.5.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bakirov R. D. Poiavlenie émbrional'nogo syvorotochnogo alpha-globulina u vzroslykh myshei posle otravleniia chetyrekhkhloristym uglerodom. Biull Eksp Biol Med. 1968 Feb;65(2):45–47. [PubMed] [Google Scholar]
  11. Baldwin R. W. Tumour specific antigens associated with chemically induced tumours. Rev Eur Etud Clin Biol. 1970 Jun-Jul;15(6):593–598. [PubMed] [Google Scholar]
  12. Brawn R. J. Possible association of embryonal antigen(s) with several primary 3-methylcholanthrene-induced murine sarcomas. Int J Cancer. 1970 Sep 15;6(2):245–249. doi: 10.1002/ijc.2910060211. [DOI] [PubMed] [Google Scholar]
  13. Bubeník J., Perlmann P., Helmstein K., Moberger G. Immune response to urinary bladder tumours in man. Int J Cancer. 1970 Jan 15;5(1):39–46. doi: 10.1002/ijc.2910050106. [DOI] [PubMed] [Google Scholar]
  14. Buffe D., Rimbaut C., Lemerle J., Schweisguth O., Burtin P. Présence d'une ferroprotéine d'origine tissulaire, l'alpha-2H, dans le sérum des enfants porteurs de tumeurs. Int J Cancer. 1970 Jan 15;5(1):85–87. doi: 10.1002/ijc.2910050111. [DOI] [PubMed] [Google Scholar]
  15. Burtin P., Von Kleist S., Sabine M. C. Loss of a normal colonic membrane antigen in human cancers of the colon. Cancer Res. 1971 Jul;31(7):1038–1041. [PubMed] [Google Scholar]
  16. Butin P., Martin E., Sabine M. C., von Kleist S. Immunological study of polyps of the colon. J Natl Cancer Inst. 1972 Jan;48(1):25–32. [PubMed] [Google Scholar]
  17. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-1972. N Engl J Med. 1972 Mar 30;286(13):713–719. doi: 10.1056/NEJM197203302861308. [DOI] [PubMed] [Google Scholar]
  18. Coggin J. H., Ambrose K. R., Anderson N. G. Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells. J Immunol. 1970 Aug;105(2):524–526. [PubMed] [Google Scholar]
  19. Coligan J. E., Lautenschleger J. T., Egan M. L., Todd C. W. Isolation and characterization of carcinoembryonic antigen. Immunochemistry. 1972 Apr;9(4):377–386. doi: 10.1016/0019-2791(72)90308-4. [DOI] [PubMed] [Google Scholar]
  20. Collatz E., Von Kleist S., Burtin P. Further investigations of circulating antibodies in colon cancer patients: on the autoantigenicity of the carcinoembryonic antigen. Int J Cancer. 1971 Sep 15;8(2):298–303. doi: 10.1002/ijc.2910080215. [DOI] [PubMed] [Google Scholar]
  21. Davidson J. F., McNicol G. P., Frank G. L., Anderson T. J., Douglas A. S. Plasminogen-activator-producing tumour. Br Med J. 1969 Jan 11;1(5636):88–91. doi: 10.1136/bmj.1.5636.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Duff R., Rapp F. Reaction of serum from pregnant hamsters with surface of cells transformed by SV40. J Immunol. 1970 Aug;105(2):521–523. [PubMed] [Google Scholar]
  23. Egan M. L., Lautenschleger J. T., Coligan J. E., Todd C. W. Radioimmune assay of carcinoembryonic antigen. Immunochemistry. 1972 Mar;9(3):289–299. doi: 10.1016/0019-2791(72)90093-6. [DOI] [PubMed] [Google Scholar]
  24. Fishman W. H., Inglis N. R., Green S., Anstiss C. L., Gosh N. K., Reif A. E., Rustigian R., Krant M. J., Stolbach L. L. Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer. Nature. 1968 Aug 17;219(5155):697–699. doi: 10.1038/219697a0. [DOI] [PubMed] [Google Scholar]
  25. Freed D. L., Taylor G. Carcinoembryonic antigen in faeces. Br Med J. 1972 Jan 8;1(5792):85–87. doi: 10.1136/bmj.1.5792.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. GASIC G., GASIC T. Removal and regeneration of the cell coating in tumour cells. Nature. 1962 Oct 13;196:170–170. doi: 10.1038/196170a0. [DOI] [PubMed] [Google Scholar]
  27. GOLD P., FREEDMAN S. O. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965 Mar 1;121:439–462. doi: 10.1084/jem.121.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Gibbs N. M., French L. W. The colon mucus antibody. J Clin Pathol. 1971 Dec;24(9):867–869. doi: 10.1136/jcp.24.9.867. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Gitlin D., Boesman M. Fetus-specific serum proteins in several mammals and their relation to human alpha-fetoprotein. Comp Biochem Physiol. 1967 May;21(2):327–336. doi: 10.1016/0010-406x(67)90793-1. [DOI] [PubMed] [Google Scholar]
  30. Gitlin D., Boesman M. Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus. J Clin Invest. 1966 Nov;45(11):1826–1838. doi: 10.1172/JCI105486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Gitlin D., Boesman M. Sites of serum alpha-fetoprotein synthesis in the human and in the rat. J Clin Invest. 1967 Jun;46(6):1010–1016. doi: 10.1172/JCI105590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Gitlin D., Perricelli A. Synthesis of serum albumin, prealbumin, alpha-foetoprotein, alpha-1-antitrypsin and transferrin by the human yolk sac. Nature. 1970 Dec 5;228(5275):995–997. doi: 10.1038/228995a0. [DOI] [PubMed] [Google Scholar]
  33. Gitlin D. Sites of alpha-fetoprotein synthesis. N Engl J Med. 1971 Dec 16;285(25):1436–1437. doi: 10.1056/NEJM197112162852517. [DOI] [PubMed] [Google Scholar]
  34. Gold P. Antigenic reversion in human cancer. Annu Rev Med. 1971;22:85–94. doi: 10.1146/annurev.me.22.020171.000505. [DOI] [PubMed] [Google Scholar]
  35. Gold P., Freedman S. O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Gold P., Gold M., Freedman S. O. Cellular location of carcinoembryonic antigens of the human digestive system. Cancer Res. 1968 Jul;28(7):1331–1334. [PubMed] [Google Scholar]
  37. Gold P., Krupey J., Ansari H. Position of the carcinoembryonic antigen of the human digestive system in ultrastructure of tumor cell surface. J Natl Cancer Inst. 1970 Aug;45(2):219–225. [PubMed] [Google Scholar]
  38. Goussev A. I., Engelhardt N. V., Masseyeff R., Camain R., Basteris B. Immunofluorescent study of alpha-foetoprotein (alpha-fp) in liver and liver tumours. II. Localization of alpha-fp in the tissues of patients with primary liver cancer (PLC). Int J Cancer. 1971 Mar 15;7(2):207–217. doi: 10.1002/ijc.2910070204. [DOI] [PubMed] [Google Scholar]
  39. Griffin M. J., Cox R. P., Grujic N. A chemical method for the isolation of HeLa cell nuclei and the nuclear localization of HeLa cell alkaline phosphatase. J Cell Biol. 1967 Apr;33(1):200–203. doi: 10.1083/jcb.33.1.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Hakomori S. I., Murakami W. T. Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines. Proc Natl Acad Sci U S A. 1968 Jan;59(1):254–261. doi: 10.1073/pnas.59.1.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Harris R., Viza D., Todd R., Phillips J., Sugar R., Jennison R. F., Marriott G., Gleeson M. H. Detection of human leukaemia associated antigens in leukaemic serum and normal embryos. Nature. 1971 Oct 22;233(5321):556–557. doi: 10.1038/233556a0. [DOI] [PubMed] [Google Scholar]
  42. Hellström I. E., Hellström K. E., Pierce G. E., Bill A. H. Demonstration of cell-bound and humoral immunity against neuroblastoma cells. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1231–1238. doi: 10.1073/pnas.60.4.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Houstek J., Masopust J., Kithier K., Rádl J. Hepatocellular carcinoma in association with a specific fetal alpha-1-globulin, fetoprotein. J Pediatr. 1968 Feb;72(2):186–193. doi: 10.1016/s0022-3476(68)80307-5. [DOI] [PubMed] [Google Scholar]
  44. Hull E. W., Carbone P. P., Gitlin D., O'Gara R. W., Kelly M. G. Alpha-fetoprotein in monkeys with hepatoma. J Natl Cancer Inst. 1969 Jun;42(6):1035–1044. [PubMed] [Google Scholar]
  45. Häkkinen I., Järvi O., Grönroos J. Sulphoglycoprotein antigens in the human alimentary canal and gastric cancer. An immunohistological study. Int J Cancer. 1968 Sep 15;3(5):572–581. doi: 10.1002/ijc.2910030506. [DOI] [PubMed] [Google Scholar]
  46. Häkkinen I., Korhonen L. K., Saxén L. The time of appearance and distribution of sulphoglycoprotein antigens in the human foetal alimentary canal. Int J Cancer. 1968 Sep 15;3(5):582–592. doi: 10.1002/ijc.2910030507. [DOI] [PubMed] [Google Scholar]
  47. Häkkinen I., Viikari S. Occurrence of fetal sulphoglycoprotein antigen in the gastric juice of patients with gastric diseases. Ann Surg. 1969 Feb;169(2):277–281. doi: 10.1097/00000658-196902000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Jehn U. W., Nathanson L., Schwartz R. S., Skinner M. In vitro lymphocyte stimulation by a soluble antigen from malignant melanoma. N Engl J Med. 1970 Aug 13;283(7):329–333. doi: 10.1056/NEJM197008132830702. [DOI] [PubMed] [Google Scholar]
  49. Karitzky D., Burtin P. Isolement de l'autoantigène responsable de la formation d'autoanticorps chez les malades atteints de cancer gastrique. Eur J Biochem. 1967 Jun;1(4):411–418. doi: 10.1111/j.1432-1033.1967.tb00089.x. [DOI] [PubMed] [Google Scholar]
  50. Kirsch J. A. Post-albumin, a foetal-specific rat plasma protein: Purification, physicochemical and immunological studies. Biochem J. 1967 Mar;102(3):763–766. doi: 10.1042/bj1020763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Kithier K., Masopust J., Rádl J. Fetal alpha-globulin of bone serum differing from fetuin. Biochim Biophys Acta. 1968 May 6;160(1):135–137. doi: 10.1016/0005-2795(68)90077-9. [DOI] [PubMed] [Google Scholar]
  52. Klavins J. V., Mesa-Tejada R., Weiss M. Human carcinoma antigens cross reacting with anti-embryonic antibodies. Nat New Biol. 1971 Dec 1;234(48):153–154. doi: 10.1038/newbio234153a0. [DOI] [PubMed] [Google Scholar]
  53. Klein G., Clifford P., Henle G., Henle W., Geering G., Old L. J. EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence. Int J Cancer. 1969 Jul 15;4(4):416–421. doi: 10.1002/ijc.2910040406. [DOI] [PubMed] [Google Scholar]
  54. Kleinman M. S., Harwell L., Turner M. D. Studies of colonic carcinoma antigens. Gut. 1971 Jan;12(1):1–10. doi: 10.1136/gut.12.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Kozower M., Fawaz K. A., Miller H. M., Kaplan M. M. Positive alpha-fetoglobulin in a case of gastric carcinoma. N Engl J Med. 1971 Nov 4;285(19):1059–1060. doi: 10.1056/NEJM197111042851906. [DOI] [PubMed] [Google Scholar]
  56. Krupey J., Gold P., Freedman S. O. Physicochemical studies of the carcinoembryonic antigens of the human digestive system. J Exp Med. 1968 Sep 1;128(3):387–398. doi: 10.1084/jem.128.3.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Krupey J., Gold P., Freedman S. O. Purification and characterization of carcinoembryonic antigens of the human digestive system. Nature. 1967 Jul 1;215(5096):67–68. doi: 10.1038/215067a0. [DOI] [PubMed] [Google Scholar]
  58. Levi M. M., Keller S., Mandl I. Antigenicity of a papillary serous cystadenocarcinoma tissue homogenate and its fractions. Am J Obstet Gynecol. 1969 Nov 15;105(6):856–861. doi: 10.1016/0002-9378(69)90091-x. [DOI] [PubMed] [Google Scholar]
  59. Lo Gerfo P., Herter F. P., Bennett S. J. Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies. Int J Cancer. 1972 Mar 15;9(2):344–348. doi: 10.1002/ijc.2910090212. [DOI] [PubMed] [Google Scholar]
  60. Lo Gerfo P., Krupey J., Hansen H. J. Demonstration of an antigen common to several varieties of neoplasia. N Engl J Med. 1971 Jul 15;285(3):138–141. doi: 10.1056/NEJM197107152850302. [DOI] [PubMed] [Google Scholar]
  61. Lo Gerfo P., Lo Gerfo F., Herter F., Barker H. G., Hansen H. J. Tumor-associated antigen in patients with carcinoma of the colon. Am J Surg. 1972 Feb;123(2):127–131. doi: 10.1016/0002-9610(72)90321-2. [DOI] [PubMed] [Google Scholar]
  62. Martin F., Martin M. S. Demonstration of antigens related to colonic cancer in the human digestive system. Int J Cancer. 1970 Nov 15;6(3):352–360. doi: 10.1002/ijc.2910060305. [DOI] [PubMed] [Google Scholar]
  63. Martin J. P., Charlionet R., Ropartz C. The presence of alpha-2H in sera from patients with malignant haemopathies and cirrhosis. Rev Eur Etud Clin Biol. 1971 Mar;16(3):266–268. [PubMed] [Google Scholar]
  64. Masopust J., Kithier K., Rádl J., Koutecký J., Kotál L. Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases. Int J Cancer. 1968 May 15;3(3):364–373. doi: 10.1002/ijc.2910030306. [DOI] [PubMed] [Google Scholar]
  65. McNeil C., Ladle J. N., Helmick W. M., Trentelman E., Wentz M. W. An antiserum to ovarian mucinous cyst fluid with colon cancer specificity. Cancer Res. 1969 Aug;29(8):1535–1540. [PubMed] [Google Scholar]
  66. Mehlman D. J., Bulkley B. H., Wiernik P. H. Serum alpha-1-fetoglobulin with gastric and prostatic carcinomas. N Engl J Med. 1971 Nov 4;285(19):1060–1061. doi: 10.1056/NEJM197111042851907. [DOI] [PubMed] [Google Scholar]
  67. Moore T. L., Kupchik H. Z., Marcon N., Zamcheck N. Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis. 1971 Jan;16(1):1–7. doi: 10.1007/BF02233781. [DOI] [PubMed] [Google Scholar]
  68. Morton D. L., Malmgren R. A., Hall W. T., Schidlovsky G. Immunologic and virus studies with human sarcomas. Surgery. 1969 Jul;66(1):152–161. [PubMed] [Google Scholar]
  69. Morton D. L., Malmgren R. A., Holmes E. C., Ketcham A. S. Demonstration of antibodies against human malignant melanoma by immunofluorescence. Surgery. 1968 Jul;64(1):233–240. [PubMed] [Google Scholar]
  70. Nairn R. C., Fothergill J. E., McEntegart M. G., Richmond H. G. Loss of Gastro-intestinal-specific Antigen in Neoplasia. Br Med J. 1962 Jun 30;1(5295):1791–1793. doi: 10.1136/bmj.1.5295.1791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Nathanson L., Fishman W. H. New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients. Cancer. 1971 Jun;27(6):1388–1397. doi: 10.1002/1097-0142(197106)27:6<1388::aid-cncr2820270619>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  72. Nishi S. Isolation and characterization of a human fetal-alpha-globulin from the sera of fetuses and a hepatoma patient. Cancer Res. 1970 Oct;30(10):2507–2513. [PubMed] [Google Scholar]
  73. Nishioka M., Ibata T., Okita K., Harada T., Fujita T. Localization of -fetoprotein in hepatoma tissues by immunofluorescence. Cancer Res. 1972 Jan;32(1):162–166. [PubMed] [Google Scholar]
  74. O'Conor G. T., Tatarinov Y. S., Abelev G. I., Uriel J. A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer. 1970 May;25(5):1091–1098. doi: 10.1002/1097-0142(197005)25:5<1091::aid-cncr2820250514>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  75. OLD L. J., BOYSE E. A. IMMUNOLOGY OF EXPERIMENTAL TUMORS. Annu Rev Med. 1964;15:167–186. doi: 10.1146/annurev.me.15.020164.001123. [DOI] [PubMed] [Google Scholar]
  76. Order S. E., Porter M., Hellman S. Hodgkin's disease: evidence for a tumor-associated antigen. N Engl J Med. 1971 Aug 26;285(9):471–474. doi: 10.1056/NEJM197108262850901. [DOI] [PubMed] [Google Scholar]
  77. PANTELOURIS E. M., HALE P. A. Developmental changes in the plasma protein pattern of the mouse. Nature. 1962 Jul 7;195:79–79. doi: 10.1038/195079a0. [DOI] [PubMed] [Google Scholar]
  78. Pearson G., Freeman G. Evidence suggesting a relationship between polyoma virus-induced transplantation antigen and normal embryonic antigen. Cancer Res. 1968 Sep;28(9):1665–1673. [PubMed] [Google Scholar]
  79. Portugal M. L., Azevedo M. S., Manso C. Serum alpha-fetoprotein and variant alkaline phosphatase in human hepatocellular carcinoma. Int J Cancer. 1970 Nov 15;6(3):383–387. doi: 10.1002/ijc.2910060308. [DOI] [PubMed] [Google Scholar]
  80. Purves L. R., Bersohn I., Geddes E. W. Serum alpha-feto-protein and primary cancer of the liver in man. Cancer. 1970 Jun;25(6):1261–1270. doi: 10.1002/1097-0142(197006)25:6<1261::aid-cncr2820250603>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  81. Purves L. R., Macnab M., Bersohn I. Serum alpha-feto-protein. I. Immunodiffusion and immuno-assay results in cases of primary cancer of the liver. S Afr Med J. 1968 Nov 2;42(42):1138–1141. [PubMed] [Google Scholar]
  82. Reynoso G., Chu T. M., Holyoke D., Cohen E., Nemoto T., Wang J. J., Chuang J., Guinan P., Murphy G. P. Carcinoembryonic antigen in patients with different cancers. JAMA. 1972 Apr 17;220(3):361–365. [PubMed] [Google Scholar]
  83. Ruoslahti E., Seppälä M., Pihko H., Vuopio P. Studies of carcino-fetal proteins. II. Biochemical comparison of -fetoprotein from human fetuses and patients with hepatocellular cancer. Int J Cancer. 1971 Sep 15;8(2):283–288. doi: 10.1002/ijc.2910080213. [DOI] [PubMed] [Google Scholar]
  84. Ruoslahti E., Seppälä M. Studies of carcino-fetal proteins. 3. Development of a radioimmunoassay for -fetoprotein. Demonstration of -fetoprotein in serum of healthy human adults. Int J Cancer. 1971 Nov 15;8(3):374–383. doi: 10.1002/ijc.2910080304. [DOI] [PubMed] [Google Scholar]
  85. Seppälä M., Ruoslahti E. Radioimmunoassay of maternal serum alpha fetoprotein during pregnancy and delivery. Am J Obstet Gynecol. 1972 Jan 15;112(2):208–212. doi: 10.1016/0002-9378(72)90117-2. [DOI] [PubMed] [Google Scholar]
  86. Spiro R. G. Glycoproteins. Annu Rev Biochem. 1970;39:599–638. doi: 10.1146/annurev.bi.39.070170.003123. [DOI] [PubMed] [Google Scholar]
  87. Spiro R. G. Studies on fetuin, a glycoprotein of fetal serum. I. Isolation, chemical composition, and physiochemical properties. J Biol Chem. 1960 Oct;235(10):2860–2869. [PubMed] [Google Scholar]
  88. Stanislawski-Birencwajg M. Specific antigens of rat embryonic serum. Cancer Res. 1967 Nov;27(11):1982–1989. [PubMed] [Google Scholar]
  89. Stillman A., Zamcheck N. Recent advances in immunologic diagnosis of digestive tract cancer. Am J Dig Dis. 1970 Nov;15(11):1003–1018. doi: 10.1007/BF02232820. [DOI] [PubMed] [Google Scholar]
  90. Stonehill E. H., Bendich A. Retrogenetic expression: the reappearance of embryonal antigens in cancer cells. Nature. 1970 Oct 24;228(5269):370–372. doi: 10.1038/228370a0. [DOI] [PubMed] [Google Scholar]
  91. Takahashi A., Yachi A., Anzai T., Wada T. Presence of a unique serum protein in sera obtained from patients with neoplastic diseases and in embryonic and neonatal sera. Clin Chim Acta. 1967 Jul;17(1):5–12. doi: 10.1016/0009-8981(67)90089-7. [DOI] [PubMed] [Google Scholar]
  92. Tatarinov Iu S. Soderzhanie embriospetsificheskogo al'fa-globulina v syvorotke ploda, novorozhdennogo i vzroslogo cheloveka v sluchae pervichnogo raka pecheni. Vopr Med Khim. 1965 Mar-Apr;11(2):20–24. [PubMed] [Google Scholar]
  93. Tee D. E., Wang M., Watkins J. Antigenic properties of human tumours. "Tumour-specific" antigens. Eur J Cancer. 1965 Nov;1(3):315–317. doi: 10.1016/0014-2964(65)90068-x. [DOI] [PubMed] [Google Scholar]
  94. Thomson D. M., Krupey J., Freedman S. O., Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969 Sep;64(1):161–167. doi: 10.1073/pnas.64.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Trouillas P. Carcino-fetal antigen in glial tumours. Lancet. 1971 Sep 4;2(7723):552–552. doi: 10.1016/s0140-6736(71)90478-8. [DOI] [PubMed] [Google Scholar]
  96. Turner M. D., Kleinman M. S., Harwell L. Studies of colonic carcinoma antigens. Gut. 1970 Dec;11(12):1064–1064. [PubMed] [Google Scholar]
  97. Uriel J., de Nechaud B., Dupiers M. Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods. Biochem Biophys Res Commun. 1972 Feb 16;46(3):1175–1180. doi: 10.1016/s0006-291x(72)80098-6. [DOI] [PubMed] [Google Scholar]
  98. Warnock M. L., Reisman R. Variant alkaline phosphatase in human hepatocellular cancers. Clin Chim Acta. 1969 Apr;24(1):5–11. doi: 10.1016/0009-8981(69)90134-x. [DOI] [PubMed] [Google Scholar]
  99. Weintraub B. D., Rosen S. W. Ectopic production of human chorionic somatomammotropin by nontrophoblastic cancers. J Clin Endocrinol Metab. 1971 Jan;32(1):94–101. doi: 10.1210/jcem-32-1-94. [DOI] [PubMed] [Google Scholar]
  100. Wise R. W., Oliver I. T. Sites of synthesis of plasma proteins in the foetal rat. Biochem J. 1966 Aug;100(2):330–333. doi: 10.1042/bj1000330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Wood W. C., Morton D. L. Host immune response to a common cell-surface antigen in human sarcomas. N Engl J Med. 1971 Mar 18;284(11):569–572. doi: 10.1056/NEJM197103182841102. [DOI] [PubMed] [Google Scholar]
  102. Yachi A., Matsuura Y., Carpenter C. M., Hyde L. Immunochemical studies on human lung cancer antigens soluble in 50 per cent saturated ammonium sulfate. J Natl Cancer Inst. 1968 Apr;40(4):663–682. [PubMed] [Google Scholar]
  103. Zamcheck N., Moore T. L., Dhar P., Kupchik H. Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens. N Engl J Med. 1972 Jan 13;286(2):83–86. doi: 10.1056/NEJM197201132860207. [DOI] [PubMed] [Google Scholar]
  104. von Kleist S., Buffe D., Burtin P. Relation entre les antigènes du liquide amniotique et du sérum foetal. Clin Chim Acta. 1968 Apr;20(1):89–94. doi: 10.1016/0009-8981(68)90389-6. [DOI] [PubMed] [Google Scholar]
  105. von Kleist S., Burtin P. Isolation of a fetal antigen from human colonic tumors. Cancer Res. 1969 Nov;29(11):1961–1964. [PubMed] [Google Scholar]
  106. von Kleist S., Burtin P. Localisation cellulaire d'un antigène embryonnaire de tumeurs coliques humaines. Int J Cancer. 1969 Nov 15;4(6):874–879. doi: 10.1002/ijc.2910040616. [DOI] [PubMed] [Google Scholar]
  107. von Kleist S., Burtin P. On the specificity of autoantibodies present in colon cancer patients. Immunology. 1966 Jun;10(6):507–515. [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES