Abstract
1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dufour M., Buu-Hoï N. P., Jacquignon P. Carcinogenic nitrogen compounds. 58. Double Skraup reaction to diaza-derivatives of some carcinogenic hydrocarbons. J Chem Soc Perkin 1. 1967;15:1415–1416. doi: 10.1039/j39670001415. [DOI] [PubMed] [Google Scholar]
- LACASSAGNE A., BUU-HOI N., ZAJDELA F. Relation entre structure moléculaire et activite cancérogène dans trois séries d'hydrocarbures aromatiques hexacycliques. C R Hebd Seances Acad Sci. 1958 Mar 10;246(10):1477–1480. [PubMed] [Google Scholar]
- LACASSAGNE A., ZAJDELA F., BUUHOI N. P., CHALVET H. Sur l'activité cancérogéne du 3.4-9.10-dibenzopyrène et de quelques-uns de ses dérivés. C R Hebd Seances Acad Sci. 1957 Jan 14;244(3):273–274. [PubMed] [Google Scholar]
- WARAVDEKAR S. S., RANADIVE K. J. Biologic testing of 3,4,9,10-dibenzpyrene. J Natl Cancer Inst. 1958 Dec;21(6):1151–1159. [PubMed] [Google Scholar]