Abstract
The results of using a standard combination of cytotoxic agents in 27 cases of secondary liver cancer are reported. A brief review of the methods available for treating hepatic metastases from solid tumours, as opposed to lymphomata, is included. The response rate depends on the site of the primary lesion. It is suggested that in patients with mammary or colorectal primary tumours, combination chemotherapy represents an advance in treatment with an objective response rate of 73% and 66% respectively in the 2 groups. The method requires no specialized equipment as neither grossly deranged liver enzymes nor jaundice are contra-indications to treatment, and toxicity is easily monitored and readily controlled.
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- ARIEL I. M. TREATMENT OF INOPERABLE PRIMARY PANCREATIC AND LIVER CANCER BY THE INTRA-ARTERIAL ADMINISTRATION OF RADIOACTIVE ISOTOPES (Y90 RADIATING MICROSPHERES). Ann Surg. 1965 Aug;162:267–278. doi: 10.1097/00000658-196508000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ARIEL I. M. The treatment of metastases to the liver with interstitial radioactive isotopes. Surg Gynecol Obstet. 1960 Jun;110:739–745. [PubMed] [Google Scholar]
- Ariel I. M., Pack G. T. Intra-arterial chemotherapy for cancer metastatic to liver. Arch Surg. 1965 Nov;91(5):851–862. doi: 10.1001/archsurg.1965.01320170145024. [DOI] [PubMed] [Google Scholar]
- Ariel I. M., Pack G. T. Treatment of inoperable cancer of the liver by intra-arterial radioactive isotopes and chemotherapy. Cancer. 1967 May;20(5):793–804. doi: 10.1002/1097-0142(1967)20:5<793::aid-cncr2820200534>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
- BRENNAN M. J., TALLEY R. W., DRAKE E. H., VAITKEVICIUS V. K., POZNANSKI A. K., BRUSH B. E. 5-FLUOROURACIL TREATMENT OF LIVER METASTASES BY CONTINUOUS HEPATIC ARTERY INFUSION VIA COURNAND CATHETER: RESULTS AND SUITABILITY FOR INTENSIVE POSTSURGICAL ADJUVANT CHEMOTHERAPY. Ann Surg. 1963 Sep;158:405–419. doi: 10.1097/00000658-196309000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burrows J. H., Talley R. W., Drake E. H., Tucker W. G. Infusion of fluorinated pyrimidines into hepatic artery for treatment of metastatic carcinoma of liver. Cancer. 1967 Nov;20(11):1886–1892. doi: 10.1002/1097-0142(196711)20:11<1886::aid-cncr2820201114>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
- Costanzi J. J., Coltman C. A., Jr Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors. Cancer. 1969 Mar;23(3):589–596. doi: 10.1002/1097-0142(196903)23:3<589::aid-cncr2820230310>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Dillard B. M. Experience with twenty-six hepatic lobectomies and extensive hepatic resections. Surg Gynecol Obstet. 1969 Aug;129(2):249–257. [PubMed] [Google Scholar]
- Donegan W. L., Harris H. S., Spratt J. S., Jr Prolonged continuous hepatic infusion. Results with fluorouracil for primary and metastatic cancer in the liver. Arch Surg. 1969 Aug;99(2):149–157. doi: 10.1001/archsurg.1969.01340140021004. [DOI] [PubMed] [Google Scholar]
- Flanagan L., Jr, Foster J. H. Hepatic resection for metastatic cancer. Am J Surg. 1967 Apr;113(4):551–557. doi: 10.1016/0002-9610(67)90206-1. [DOI] [PubMed] [Google Scholar]
- Hanham I. W., Newton K. A., Westbury G. Seventy-five cases of solid tumours treated by a modified quadruple chemotherapy regime. Br J Cancer. 1971 Sep;25(3):462–478. doi: 10.1038/bjc.1971.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- INGOLD J. A., REED G. B., KAPLAN H. S., BAGSHAW M. A. RADIATION HEPATITIS. Am J Roentgenol Radium Ther Nucl Med. 1965 Jan;93:200–208. [PubMed] [Google Scholar]
- LAWRENCE W., Jr REGIONAL CANCER CHEMOTHERAPY: AN EVALUATION. Prog Clin Cancer. 1965;10:341–393. [PubMed] [Google Scholar]
- Labelle J. J., Lucas R. J., Eisenstein B., Reed M. D., Vaitkevicius V. K., Wilson G. S. Hepatic artery catheterization for chemotherapy. Arch Surg. 1968 Apr;96(4):683–692. doi: 10.1001/archsurg.1968.01330220199029. [DOI] [PubMed] [Google Scholar]
- Lahiri S. R., Boileau G., Hall T. C. Treatment of metastatic colorectal carcinoma with 5-fluorouracil by mouth. Cancer. 1971 Oct;28(4):902–906. doi: 10.1002/1097-0142(1971)28:4<902::aid-cncr2820280413>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
- Mansfield C. M., Kramer S., Southard M. E., Mandell G. Prognosis in patients with metastatic liver disease diagnosed by liver scan. Radiology. 1969 Jul;93(1):77–84. doi: 10.1148/23.1.77. [DOI] [PubMed] [Google Scholar]
- Murray-Lyon I. M., Parsons V. A., Blendis L. M., Dawson J. L., Rake M. O., Laws J. W., Williams R. Treatment of secondary hepatic tumours by ligation of hepatic artery and infusion of cytotoxic drugs. Lancet. 1970 Jul 25;2(7665):172–175. doi: 10.1016/s0140-6736(70)92533-x. [DOI] [PubMed] [Google Scholar]
- Rapoport A. H., Burleson R. L. Survival of patients treated with systemic fluorouracil for hepatic metastases. Surg Gynecol Obstet. 1970 May;130(5):773–777. [PubMed] [Google Scholar]
- SULLIVAN R. D., NORCROSS J. W., WATKINS E., Jr CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION. N Engl J Med. 1964 Feb 13;270:321–327. doi: 10.1056/NEJM196402132700701. [DOI] [PubMed] [Google Scholar]
- Sullivan R. D., Zurek W. Z. Chemotherapy for liver cancer by protracted ambulatory infusion. JAMA. 1965 Nov 1;194(5):481–486. [PubMed] [Google Scholar]
- Wilson R. E., Piro A. J., Aliapoulios M. A., Moore F. D. Treatment of metastatic breast cancer with a combination of adrenalectomy and 5-fluorouracil. Progress report. Cancer. 1971 Oct;28(4):962–966. doi: 10.1002/1097-0142(1971)28:4<962::aid-cncr2820280420>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]


