Abstract
The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increased rate being caused simply by increased vulnerability of old animals was not as plausible as the alternative hypothesis of the carcinogen acting to some extent cumulatively.
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Selected References
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- DOLL R., HILL A. B. MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J. 1964 Jun 6;1(5396):1460–CONCL. doi: 10.1136/bmj.1.5396.1460. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies R. F., Day T. D. A study of the comparative carcinogenicity of cigarette and cigar smoke condensate on mouse skin. Br J Cancer. 1969 Jun;23(2):363–368. doi: 10.1038/bjc.1969.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pike M. C. A method of analysis of a certain class of experiments in carcinogenesis. Biometrics. 1966 Mar;22(1):142–161. [PubMed] [Google Scholar]