Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1970 Dec;24(4):853–860. doi: 10.1038/bjc.1970.101

Studies of the Rat Immune Response to Plasmacytoma 5563 in C3H Mice

O Fakhri, J R Hobbs
PMCID: PMC2008713  PMID: 5503607

Abstract

Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.

Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.

This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.

Full text

PDF
853

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander P., Delorme E. J., Hamilton L. D., Hall J. G. Effect of nucleic acids from immune lymphocytes on rat sarcomata. Nature. 1967 Feb 11;213(5076):569–572. doi: 10.1038/213569a0. [DOI] [PubMed] [Google Scholar]
  2. Delorme E. J., Hodgett J., Hall J. G., Alexander P. The cellular immune response to primary sarcomata in rats. I. The significance of large basophilic cells in the thoracic duct lymph following antigenic challenge. Proc R Soc Lond B Biol Sci. 1969 Nov 18;174(1035):229–236. doi: 10.1098/rspb.1969.0089. [DOI] [PubMed] [Google Scholar]
  3. GORER P. A., AMOS D. B. Passive immunity in mice against C57BL leukosis E.L. 4 by means of iso-immune serum. Cancer Res. 1956 May;16(4):338–343. [PubMed] [Google Scholar]
  4. Irvin G. L., 3rd, Eustace J. C., Fahey J. L. Inhancement activity of mouse immunoglobulin classes. J Immunol. 1967 Dec;99(6):1085–1091. [PubMed] [Google Scholar]
  5. KLEIN E., KLEIN G. ANTIGENIC PROPERTIES OF LYMPHOMAS INDUCED BY THE MOLONEY AGENT. J Natl Cancer Inst. 1964 Mar;32:547–568. [PubMed] [Google Scholar]
  6. OLD L. J., BOYSE E. A. IMMUNOLOGY OF EXPERIMENTAL TUMORS. Annu Rev Med. 1964;15:167–186. doi: 10.1146/annurev.me.15.020164.001123. [DOI] [PubMed] [Google Scholar]
  7. Southam C. M., Dizon Q. S. Rejection of human cancer transplants by tolerant rats following treatment with allogenic lymphoid cells. Cancer Res. 1969 Jul;29(7):1428–1436. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES