Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1973 Mar;27(3):212–217. doi: 10.1038/bjc.1973.26

Ferritinaemia in Leukaemia and Hodgkin's Disease

P A E Jones, F M Miller, M Worwood, A Jacobs
PMCID: PMC2008776  PMID: 4511989

Abstract

The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron. In Hodgkin's disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release. Increased concentrations of circulating ferritin have also been observed in a few cases of chronic leukaemia and myelomatosis.

Full text

PDF
212

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Addison G. M., Beamish M. R., Hales C. N., Hodgkins M., Jacobs A., Llewellin P. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J Clin Pathol. 1972 Apr;25(4):326–329. doi: 10.1136/jcp.25.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aungst C. W. Ferritin in body fluids. J Lab Clin Med. 1968 Mar;71(3):517–522. [PubMed] [Google Scholar]
  3. Beamish M. R., Davies A. G., Eakins J. D., Jacobs A., Trevett D. The measurement of reticuloendothelial iron release using iron-dextran. Br J Haematol. 1971 Dec;21(6):617–622. doi: 10.1111/j.1365-2141.1971.tb02724.x. [DOI] [PubMed] [Google Scholar]
  4. Beamish M. R., Jones P. A., Trevett D., Evans I. H., Jacobs A. Iron metabolism in Hodgkin's disease. Br J Cancer. 1972 Dec;26(6):444–452. doi: 10.1038/bjc.1972.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carbone P. P., Kaplan H. S., Musshoff K., Smithers D. W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed] [Google Scholar]
  6. Caroline L., Rosner F., Kozinn P. J. Elevated serum iron, low unbound transferrin and candidiasis in acute leukemia. Blood. 1969 Oct;34(4):441–451. [PubMed] [Google Scholar]
  7. Cartwright G. E., Lee G. R. The anaemia of chronic disorders. Br J Haematol. 1971 Aug;21(2):147–152. doi: 10.1111/j.1365-2141.1971.tb03424.x. [DOI] [PubMed] [Google Scholar]
  8. Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lee J. C., Richter G. W. Distinctive properties of ferritin from the Reuber H-35 rat hepatoma. Cancer Res. 1971 May;31(5):566–572. [PubMed] [Google Scholar]
  10. NATHAN D. G., BERLIN N. I. Studies of the rate of production and life span of erythrocytes in acute leukemia. Blood. 1959 Aug;14(8):935–949. [PubMed] [Google Scholar]
  11. REISSMANN K. R., DIETRICH M. R. On the presence of ferritin in the peripheral blood of patients with hepatocellular disease. J Clin Invest. 1956 Jun;35(6):588–595. doi: 10.1172/JCI103312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Richter G. W. Comparison of ferritins from neoplastic and non-neoplastic human cells. Nature. 1965 Aug 7;207(997):616–618. doi: 10.1038/207616a0. [DOI] [PubMed] [Google Scholar]
  13. YOUNG D. S., HICKS J. M. METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON. J Clin Pathol. 1965 Jan;18:98–102. doi: 10.1136/jcp.18.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES