Abstract
A retrospective detailed study of 272 cases of breast carcinoma treated by radical mastectomy was published by Hamlin (1968). An extended analysis of the material for 258 of these cases is now reported.
Data for 21 prognostic factors from 258 patients have been subjected to multiple regression analysis to determine the independent effect and thus the relative importance of each factor. The findings confirm previous single factor analyses and demonstrate that nine of the factors are independently associated with survival.
Mathematical manipulation of the information obtained in this analysis allowed a risk score to be allotted to each patient. Grouping of patients by the prediction scores is found in this series to be more closely related to survival than is clinical staging of the same patients.
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Selected References
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- BLACK M. M., SPEER F. D. Sinus histiocytosis of lymph nodes in cancer. Surg Gynecol Obstet. 1958 Feb;106(2):163–175. [PubMed] [Google Scholar]
- BLOOM H. J., RICHARDSON W. W., HARRIES E. J. Natural history of untreated breast cancer (1805-1933). Comparison of untreated and treated cases according to histological grade of malignancy. Br Med J. 1962 Jul 28;2(5299):213–221. doi: 10.1136/bmj.2.5299.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cutler S. J., Black M. M., Mork T., Harvei S., Freeman C. Further observations on prognostic factors in cancer of the female breast. Cancer. 1969 Oct;24(4):653–667. doi: 10.1002/1097-0142(196910)24:4<653::aid-cncr2820240402>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
- Hamlin I. M. Possible host resistance in carcinoma of the breast: a histological study. Br J Cancer. 1968 Sep;22(3):383–401. doi: 10.1038/bjc.1968.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Juret P., Aubert C., Le Borgne De Kaouël Valeur pronostique de la cholestérolémie chez les femmes atteintes de cancer du sein. Pathol Biol. 1967 May;15(9):515–518. [PubMed] [Google Scholar]
- MCKENZIE A. Cancer of the female breast, mortality, and the menopause. Lancet. 1955 Nov 26;269(6900):1129–1130. doi: 10.1016/s0140-6736(55)92964-0. [DOI] [PubMed] [Google Scholar]
- Myers M. H., Axtell L. M., Zelen M. The use of prognostic factors in predicting survival for breast cancer patients. J Chronic Dis. 1966 Aug;19(8):923–933. doi: 10.1016/0021-9681(66)90008-7. [DOI] [PubMed] [Google Scholar]
- TREVES N., HOLLEB A. I. A report of 549 cases of breast cancer in women 35 years of age or younger. Surg Gynecol Obstet. 1958 Sep;107(3):271–283. [PubMed] [Google Scholar]