Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1971 Dec;25(4):711–720. doi: 10.1038/bjc.1971.86

Immunological Properties of Neoplastic Neural Tissues

H R Wickremesinghe, P O Yates
PMCID: PMC2008866  PMID: 5004175

Abstract

The results are presented of the examination of 28 neoplasms from the nervous system for an organ-specific antigenic material demonstrated in glial cells and myelin, using gel diffusion, immunocytotoxicity and immunofluorescence techniques.

The antigenic material was demonstrable in benign gliomas and in those of low-grade malignancy, but not in the more malignant gliomas and non-gliomatous neoplasia.

The implications of the loss of specific antigenic material with reference to cell structure and function, and some fallacies in the interpretation of the significance of tissue specific antigen in carcinogenesis are discussed.

Full text

PDF
711

Images in this article

714-1Figs. 1-4
on p.714-1
714-3Figs. 5-7
on p.714-3
714-5Figs. 8-11
on p.714-5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HIRAMOTO R., BERNECKY J., JURANDOWSKI J., PRESSMAN D. Immunohistochemical staining properties of the N-2-FAA rat hepatoma. Cancer Res. 1961 Nov;21:1372–1376. [PubMed] [Google Scholar]
  2. HIRAMOTO R., JURAND J., BERNECKY J., PRESSMAN D. Lack of staining of testicular tumors by anti-sperm and anti-testis antibodies. Proc Soc Exp Biol Med. 1962 Nov;111:505–507. doi: 10.3181/00379727-111-27837. [DOI] [PubMed] [Google Scholar]
  3. HUGHES P. E., LOUIS C. J., DINEEN J. K., SPECTOR W. G. Role of organ-specific antigen during 4-dimethylaminoazobenzene carcinogenesis in the rat liver. Nature. 1957 Aug 10;180(4580):289–290. doi: 10.1038/180289a0. [DOI] [PubMed] [Google Scholar]
  4. MAYERSBACH H. Unspecific interactions between serum and tissue sections in the fluorescent-antibody technic for tracing antigens in tissues. J Histochem Cytochem. 1959 Nov;7:427–427. doi: 10.1177/7.6.427. [DOI] [PubMed] [Google Scholar]
  5. NAIRN R. C., RICHMOND H. G., McENTEGART M. G., FOTHERGILL J. E. Immunological differences between normal and malignant cells. Br Med J. 1960 Nov 5;2(5209):1335–1340. doi: 10.1136/bmj.2.5209.1335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Nairn R. C., Fothergill J. E., McEntegart M. G., Richmond H. G. Loss of Gastro-intestinal-specific Antigen in Neoplasia. Br Med J. 1962 Jun 30;1(5295):1791–1793. doi: 10.1136/bmj.1.5295.1791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SOROF S., COHEN P. P. Electrophoretic and ultracentrifugal studies on the soluble proteins of various tumors and of livers from rats fed 4-dimethylaminoazobenzene. Cancer Res. 1951 May;11(5):376–382. [PubMed] [Google Scholar]
  8. TEE E. H., WANG M., WATKINS J. A CRYOSTAT METHOD FOR THE EXTRACTION OF SOLUBLE TISSUE COMPONENTS. Nature. 1964 Nov 14;204:682–684. doi: 10.1038/204682a0. [DOI] [PubMed] [Google Scholar]
  9. VOGT P. Distribution of tissue-specific antigens in centrifugal fractions of rat liver. Nature. 1958 Dec 27;182(4652):1807–1808. doi: 10.1038/1821807a0. [DOI] [PubMed] [Google Scholar]
  10. WEILER E. Antigenic differences between normal hamster kidney and stilboestrol induced kidney carcinoma: histological demonstration by means of fluorescing antibodies. Br J Cancer. 1956 Sep;10(3):560–563. doi: 10.1038/bjc.1956.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. WELLER T. H., COONS A. H. Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789–794. doi: 10.3181/00379727-86-21235. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES