Abstract
The cellular composition of Hodgkin's tissue from two patients has been examined. The labelling pattern with 3H-TdR has been studied on in vivo labelled imprints and histological sections. The relative proportions of the various classes of cells are maintained when Hodgkin's tissue increases in bulk. Histological progression from LP/MC to MC Hodgkin's disease was associated with an increase in aneuploidy of the Hodgkin cell line and an increase in the proportion of large basophilic blast cells. Splenic Hodgkin's disease in the same patient contained fewer aneuploid cells. The significance of these findings in terms of the histogenesis of Hodgkin and Sternberg-Reed cells is discussed.
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- Alexander P., Hall J. G. The role of immunoblasts in host resistance and immunotherapy of primary sarcomata. Adv Cancer Res. 1970;13:1–37. doi: 10.1016/s0065-230x(08)60162-1. [DOI] [PubMed] [Google Scholar]
- Engeset A., Cooper E. H., Brennhovd I., Hoeg K. The thoracic duct lymph in Hodgkin's disease. II. Quantitative analysis of the cellular composition of the lymph. Int J Cancer. 1971 Jul 15;8(1):113–121. doi: 10.1002/ijc.2910080115. [DOI] [PubMed] [Google Scholar]
- Halie M. R., Eibergen R., Nieweg H. O. Observations on abnormal cells in the peripheral blood and spleen in Hodgkin's disease. Br Med J. 1972 Jun 10;2(5814):609–611. doi: 10.1136/bmj.2.5814.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peckham M. J., Cooper E. H. Proliferation characteristics of the various classes of cells in Hodgkin's disease. Cancer. 1969 Jul;24(1):135–146. doi: 10.1002/1097-0142(196907)24:1<135::aid-cncr2820240118>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Rappaport H., Strum S. B. Vascular invasion in Hodgkin's disease: its incidence and relationship to the spread of the disease. Cancer. 1970 Jun;25(6):1304–1313. doi: 10.1002/1097-0142(197006)25:6<1304::aid-cncr2820250608>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Schiffer L. M. Human lymphocyte proliferation: DNA synthesis time. Cell Tissue Kinet. 1971 Nov;4(6):585–595. doi: 10.1111/j.1365-2184.1971.tb01566.x. [DOI] [PubMed] [Google Scholar]